FisB

• Description: membrane fission protein, mediates membrane fission during sporulation
  
  

Gene name	fisB
Synonyms	yunB
Essential	no
Product	membrane fission protein
Function	release of the forespore into the mother cell cytoplasm
Gene expression levels in SubtiExpress: fisB
MW, pI	27 kDa, 9.529
Gene length, protein length	762 bp, 254 aa
Immediate neighbours	lytH, yunC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

membrane dynamics, sporulation proteins, membrane proteins

This gene is a member of the following regulons

SigE regulon

The gene

Basic information

• Locus tag: BSU32350

Phenotypes of a mutant

• reduced sporulation efficiency (12 - 15%) PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • mediates membrane fission during sporulation PubMed
  • binds cardiolipin PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane PubMed
  • forms dynamic foci which become immobilized at the site of membrane fission PubMed

Database entries

• Structure:

• UniProt: O32131

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: fisB PubMed

• Expression browser: fisB PubMed

• Sigma factor: SigE PubMed

• Regulation:
  • expressed early during sporulation in the mother cell (SigE) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Irene S Tan, Kumaran S Ramamurthi
Membrane remodeling: FisB will do in a pinch.
Curr Biol: 2013, 23(6);R251-3
[PubMed:23518060] [WorldCat.org] [DOI] (I p)