SpoVD

• Description: mother-cell specific penicillin-binding protein (spore cortex)
  
  

Gene name	spoVD
Synonyms
Essential	no
Product	penicillin-binding protein (spore cortex)
Function	spore morphogenesis
Gene expression levels in SubtiExpress: spoVD
Interactions involving this protein in SubtInteract: SpoVD
MW, pI	71 kDa, 8.85
Gene length, protein length	1935 bp, 645 aa
Immediate neighbours	pbpB, murE
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, sporulation proteins, membrane proteins

This gene is a member of the following regulons

SigE regulon, SpoIIID regulon

The gene

Basic information

• Locus tag: BSU15170

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: protects SpoVE from proteolytic degradation PubMed

• Protein family:

• Paralogous protein(s): PbpB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: intramolecular disulfide bonds between two Cys residues are reduced by StoA, this is rquired for activity of SpoVD PubMed

• Interactions:
  • SpoVD-StoA PubMed
  • SpoVD-SpoVE PubMed

• Localization: intermembrane space that separates forespores from mother cells PubMed

Database entries

• Structure:

• UniProt: Q03524

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoVD PubMed

• Expression browser: spoVD PubMed

• Sigma factor: SigE PubMed

• Regulation:
  • expressed during sporulation in the mother cell (SigE) PubMed

• Regulatory mechanism:

• • SpoIIID: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • 1A975 ( spoVD::cat), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: