CtaO

• Description: heme O synthase (minor enzyme)
  
  

Gene name	ctaO
Synonyms	yjdK
Essential	no
Product	heme O synthase (minor enzyme)
Function	heme biosynthesis
Gene expression levels in SubtiExpress: ctaO
MW, pI	36 kDa, 10.121
Gene length, protein length	987 bp, 329 aa
Immediate neighbours	yjdJ, cotT
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors, membrane proteins

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU12080

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: Protoheme IX farnesyltransferase subfamily (according to Swiss-Prot)

• Paralogous protein(s): CtaB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O31652

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ctaO PubMed

• Expression browser: ctaO PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:
  • the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947

M Throne-Holst, L Hederstedt
The Bacillus subtilis ctaB paralogue, yjdK, can complement the heme A synthesis deficiency of a CtaB-deficient mutant.
FEMS Microbiol Lett: 2000, 183(2);247-51
[PubMed:10675592] [WorldCat.org] [DOI] (P p)