Difference between revisions of "CdaS"
| Line 1: | Line 1: | ||
| − | * '''Description:''' | + | * '''Description:''' sporulation-specific diadenylate cyclase, synthesis of c-di-AMP<br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || sporulation-specific diadenylate cyclase |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || synthesis of c-di-AMP |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU19430 yojJ] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU19430 yojJ] | ||
| Line 67: | Line 67: | ||
* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| + | ** synthesis of c-di-AMP from two molecules of ATP {{PubMed|23192352}} | ||
* '''Protein family:''' | * '''Protein family:''' | ||
| − | * '''Paralogous protein(s):''' [[ | + | * '''Paralogous protein(s):''' [[CdaA]] |
=== Extended information on the protein === | === Extended information on the protein === | ||
| Line 76: | Line 77: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' contains a DAC domain | + | * '''Domains:''' contains a DAC domain involved in the synthesis of c-di-AMP {{PubMed|21566650}} |
* '''Modification:''' | * '''Modification:''' | ||
| Line 84: | Line 85: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
| − | * '''Localization:''' | + | * '''[[Localization]]:''' |
=== Database entries === | === Database entries === | ||
| Line 106: | Line 107: | ||
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yojJ_2118504_2119127_-1 yojJ] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yojJ_2118504_2119127_-1 yojJ] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
| Line 138: | Line 139: | ||
<pubmed> 18714086</pubmed> | <pubmed> 18714086</pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | <pubmed>21566650, </pubmed> | + | <pubmed>21566650, 23192352 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 11:53, 30 November 2012
- Description: sporulation-specific diadenylate cyclase, synthesis of c-di-AMP
| Gene name | yojJ |
| Synonyms | |
| Essential | no |
| Product | sporulation-specific diadenylate cyclase |
| Function | synthesis of c-di-AMP |
| Gene expression levels in SubtiExpress: yojJ | |
| MW, pI | 22 kDa, 5.367 |
| Gene length, protein length | 621 bp, 207 aa |
| Immediate neighbours | yojK, yojI |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
metabolism of signalling nucleotides, sporulation proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU19430
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- synthesis of c-di-AMP from two molecules of ATP PubMed
- Protein family:
- Paralogous protein(s): CdaA
Extended information on the protein
- Kinetic information:
- Domains: contains a DAC domain involved in the synthesis of c-di-AMP PubMed
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 2FB5 (the protein of B. cereus, 48% identity, 81% similarity)
- UniProt: O31854
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- GP983 (yojJ::ermC), available in Jörg Stülke's lab
- GP1360 (yojJ::spc), available in Jörg Stülke's lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Ute Römling
Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea.
Sci Signal: 2008, 1(33);pe39
[PubMed:18714086]
[WorldCat.org]
[DOI]
(I e)
Original publications
Felix M P Mehne, Katrin Gunka, Hinnerk Eilers, Christina Herzberg, Volkhard Kaever, Jörg Stülke
Cyclic di-AMP homeostasis in bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth.
J Biol Chem: 2013, 288(3);2004-17
[PubMed:23192352]
[WorldCat.org]
[DOI]
(I p)
Yaara Oppenheimer-Shaanan, Ezequiel Wexselblatt, Jehoshua Katzhendler, Eylon Yavin, Sigal Ben-Yehuda
c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis.
EMBO Rep: 2011, 12(6);594-601
[PubMed:21566650]
[WorldCat.org]
[DOI]
(I p)
