GabP

• Description: gamma-amino butyric acid permease
  
  

Gene name	gabP
Synonyms	nrg-21
Essential	no
Product	gamma-amino butyric acid permease
Function	utilization of gamma-amino butyric acid
Gene expression levels in SubtiExpress: gabP
Metabolic function and regulation of this protein in SubtiPathways: Ala, Gly, Ser
MW, pI	50 kDa, 9.45
Gene length, protein length	1407 bp, 469 aa
Immediate neighbours	cotA, yeaB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, utilization of amino acids, membrane proteins

This gene is a member of the following regulons

CodY regulon, TnrA regulon

The gene

Basic information

• Locus tag: BSU06310

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: secondary amino acid transporter

• Paralogous protein(s): AapA, HutM, RocC, RocE, YbgF, YbxG, YdgF, YtnA, YvbW

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P46349

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: gabP PubMed

• Expression browser: gabP PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed in the absence of good nitrogen sources (glutamine or ammonium) (TnrA) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • TnrA: transcription activation PubMed
  • CodY: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

A E Ferson, L V Wray, S H Fisher
Expression of the Bacillus subtilis gabP gene is regulated independently in response to nitrogen and amino acid availability.
Mol Microbiol: 1996, 22(4);693-701
[PubMed:8951816] [WorldCat.org] [DOI] (P p)