Difference between revisions of "ManP"

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** induced by mannose ([[ManR]]) {{PubMed|20139185}}
 
** induced by mannose ([[ManR]]) {{PubMed|20139185}}
 
** repressed by glucose ([[ManR]]) {{PubMed|20139185}}
 
** repressed by glucose ([[ManR]]) {{PubMed|20139185}}
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** strongly induced in response to glucose starvation in M9 medium {{PubMed|23033921}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
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=References=
 
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'''Additional publications:''' {{PubMed|23033921}}
 
<pubmed>10627040 17218307 10627040, 20139185 </pubmed>
 
<pubmed>10627040 17218307 10627040, 20139185 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 19:09, 8 October 2012

Gene name manP
Synonyms yjdD
Essential no
Product trigger enzyme: mannose-specific phosphotransferase system, EIIBCA
Function mannose uptake and phosphorylation, control of ManR activity
Gene expression levels in SubtiExpress: manP
Interactions involving this protein in SubtInteract: ManP
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 61 kDa, 6.715
Gene length, protein length 1767 bp, 589 aa
Immediate neighbours manR, manA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ManP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ManP expression.png



















Categories containing this gene/protein

phosphotransferase systems, utilization of specific carbon sources, transcription factors and their control, trigger enzyme, membrane proteins, phosphoproteins

This gene is a member of the following regulons

ManR regulon

The gene

Basic information

  • Locus tag: BSU12010

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transport and concomitant phosphorylation of mannose
  • Protein family: PTS permease, fructose/ mannitol permease (Fru) family PubMed
  • Paralogous protein(s): FruA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation on Ser-365 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2R48 (IIB domain)
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced by mannose (ManR) PubMed
    • repressed by glucose (ManR) PubMed
    • strongly induced in response to glucose starvation in M9 medium PubMed
  • Regulatory mechanism:
    • ManR: transcription activation in the presence of mannose and absence of glucose PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed