SpoVD

• Description: mother-cell specific penicillin-binding protein (spore cortex)
  
  

Gene name	spoVD
Synonyms
Essential	no
Product	penicillin-binding protein (spore cortex)
Function	spore morphogenesis
Gene expression levels in SubtiExpress: spoVD
Interactions involving this protein in SubtInteract: SpoVD
MW, pI	71 kDa, 8.85
Gene length, protein length	1935 bp, 645 aa
Immediate neighbours	pbpB, murE
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, sporulation proteins, membrane proteins

This gene is a member of the following regulons

SigE regulon, SpoIIID regulon

The gene

Basic information

• Locus tag: BSU15170

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: protects SpoVE from proteolytic degradation PubMed

• Protein family:

• Paralogous protein(s): PbpB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: intramolecular disulfide bonds between two Cys residues are reduced by StoA, this is rquired for activity of SpoVD PubMed

• Interactions:
  • SpoVD-StoA PubMed
  • SpoVD-SpoVE PubMed

• Localization: intermembrane space that separates forespores from mother cells PubMed

Database entries

• Structure:

• UniProt: Q03524

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoVD PubMed

• Expression browser: spoVD PubMed

• Sigma factor: SigE PubMed

• Regulation:
  • expressed during sporulation in the mother cell (SigE) PubMed

• Regulatory mechanism:

• • SpoIIID: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • 1A975 ( spoVD::cat), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: