RadC

• Description: probable DNA repair protein
  
  

Gene name	radC
Synonyms	ysxA
Essential	no
Product	probable DNA repair protein
Function	DNA repair
Gene expression levels in SubtiExpress: radC
MW, pI	25 kDa, 7.829
Gene length, protein length	693 bp, 231 aa
Immediate neighbours	mreB, maf
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination, genetic competence, cell envelope stress proteins (controlled by SigM, V, W, X, Y), phosphoproteins

This gene is a member of the following regulons

ComK regulon, SigM regulon

The gene

Basic information

• Locus tag: BSU28040

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: radC family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-59 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: Cytoplasm (Homogeneous) PubMed

Database entries

• Structure:

• UniProt: Q02170

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: radC (according to DBTBS), radC-mreB-mreC-mreD-minC-minD PubMed

• Expression browser: radC PubMed

• Sigma factor: SigM PubMed

• Regulation:
  • expressed in response to cell wall antibiotics, ethanol, heat, acid, and superoxide stress (SigM) PubMed
  • expression is reduced in a SigV mutant PubMed

• Regulatory mechanism:
  • ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed