Difference between revisions of "CoaX"

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* '''Description:''' hypothetical protein  <br/><br/>
  
 
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|style="background:#ABCDEF;" align="center"|'''Function''' || coenyzmeA synthesis
 
|style="background:#ABCDEF;" align="center"|'''Function''' || coenyzmeA synthesis
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU00700 coaX]
 
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/CoA_synthesis.html Coenzyme A]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/CoA_synthesis.html Coenzyme A]'''
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|colspan="2" | '''Genetic context''' <br/> [[Image:yacB_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yacB_context.gif]]
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=coaX_79092_79868_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:coaX_expression.png|500px]]
 
 
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* '''Operon:''' ''[[coaX]]-[[yacC]]'' {{PubMed|18179421}}
 
* '''Operon:''' ''[[coaX]]-[[yacC]]'' {{PubMed|18179421}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=coaX_79092_79868_1 coaX] {{PubMed|22383849}}
 
  
 
* '''Sigma factor:''' [[SigM]] {{PubMed|18179421}}
 
* '''Sigma factor:''' [[SigM]] {{PubMed|18179421}}

Revision as of 10:22, 7 August 2012

  • Description: hypothetical protein

Gene name coaX
Synonyms yacB
Essential no
Product pantothenate kinase (EC 2.7.1.33)
Function coenyzmeA synthesis
Metabolic function and regulation of this protein in SubtiPathways:
Coenzyme A
MW, pI 26 kDa, 8.37
Gene length, protein length 699 bp, 233 aa
Immediate neighbours ftsH, yacC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YacB context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

biosynthesis of cofactors, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

  • Locus tag: BSU00700

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate (according to Swiss-Prot)
  • Protein family: type III pantothenate kinase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2H3G (from Bacillus anthracis str. ames, 75% identity, 88% similarity) PubMed
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Warawan Eiamphungporn, John D Helmann
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.
Mol Microbiol: 2008, 67(4);830-48
[PubMed:18179421] [WorldCat.org] [DOI] (P p)

Leisl A Brand, Erick Strauss
Characterization of a new pantothenate kinase isoform from Helicobacter pylori.
J Biol Chem: 2005, 280(21);20185-8
[PubMed:15795230] [WorldCat.org] [DOI] (P p)