Difference between revisions of "PksS"
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Revision as of 09:30, 13 April 2012
- Description: cytochrome P450, hydroxylase of the polyketide bacillaene produced by the pks cluster
| Gene name | pksS |
| Synonyms | |
| Essential | no |
| Product | hydroxylase of the polyketide produced by the pks cluster |
| Function | polyketide synthesis |
| MW, pI | 43 kDa, 6.121 |
| Gene length, protein length | 1128 bp, 376 aa |
| Immediate neighbours | pksR, ymzB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
miscellaneous metabolic pathways, biosynthesis of antibacterial compounds
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU17230
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
- A mutation was found in this gene after evolution under relaxed selection for sporulation PubMed
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- hydroxylation of dihydrobacillaene PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O31785
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Christopher T Brown, Laura K Fishwick, Binna M Chokshi, Marissa A Cuff, Jay M Jackson, Travis Oglesby, Alison T Rioux, Enrique Rodriguez, Gregory S Stupp, Austin H Trupp, James S Woollcombe-Clarke, Tracy N Wright, William J Zaragoza, Jennifer C Drew, Eric W Triplett, Wayne L Nicholson
Whole-genome sequencing and phenotypic analysis of Bacillus subtilis mutants following evolution under conditions of relaxed selection for sporulation.
Appl Environ Microbiol: 2011, 77(19);6867-77
[PubMed:21821766]
[WorldCat.org]
[DOI]
(I p)
Jason J Reddick, Stephanie A Antolak, Gregory M Raner
PksS from Bacillus subtilis is a cytochrome P450 involved in bacillaene metabolism.
Biochem Biophys Res Commun: 2007, 358(1);363-7
[PubMed:17482575]
[WorldCat.org]
[DOI]
(P p)
