Difference between revisions of "AlbA"
Line 1: | Line 1: | ||
− | * '''Description:''' antilisterial bacteriocin (subtilosin) production <br/><br/> | + | * '''Description:''' radical S-adenosylmethionine enzyme, antilisterial bacteriocin (subtilosin) production <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || radical S-adenosylmethionine enzyme |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || antilisterial bacteriocin (subtilosin) production | |style="background:#ABCDEF;" align="center"|'''Function''' || antilisterial bacteriocin (subtilosin) production | ||
Line 64: | Line 64: | ||
* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
− | + | ** catalyzes thioether bond formation in subtilosin A {{PubMed|22366720}} | |
* '''Protein family:''' | * '''Protein family:''' | ||
Line 77: | Line 77: | ||
* '''Modification:''' | * '''Modification:''' | ||
− | * '''Cofactor(s):''' contains | + | * '''Cofactor(s):''' contains two [4Fe-4S] clusters {{PubMed|22366720}} |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
Line 134: | Line 134: | ||
=References= | =References= | ||
− | <pubmed>10809709,10572140,,15743949,10809710,10572140,17720793, 17190806 </pubmed> | + | <pubmed>10809709,10572140,,15743949,10809710,10572140,17720793, 17190806 22366720 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] |
Revision as of 15:44, 4 March 2012
- Description: radical S-adenosylmethionine enzyme, antilisterial bacteriocin (subtilosin) production
Gene name | albA |
Synonyms | ywiA |
Essential | no |
Product | radical S-adenosylmethionine enzyme |
Function | antilisterial bacteriocin (subtilosin) production |
MW, pI | 51 kDa, 6.195 |
Gene length, protein length | 1344 bp, 448 aa |
Immediate neighbours | sboX, albB |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
Categories containing this gene/protein
miscellaneous metabolic pathways, biosynthesis of antibacterial compounds
This gene is a member of the following regulons
AbrB regulon, ResD regulon, Rok regulon
The gene
Basic information
- Locus tag: BSU37370
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- catalyzes thioether bond formation in subtilosin A PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): contains two [4Fe-4S] clusters PubMed
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P71011
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Leif Flühe, Thomas A Knappe, Michael J Gattner, Antje Schäfer, Olaf Burghaus, Uwe Linne, Mohamed A Marahiel
The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A.
Nat Chem Biol: 2012, 8(4);350-7
[PubMed:22366720]
[WorldCat.org]
[DOI]
(I e)
Mark A Strauch, Benjamin G Bobay, John Cavanagh, Fude Yao, Angelo Wilson, Yoann Le Breton
Abh and AbrB control of Bacillus subtilis antimicrobial gene expression.
J Bacteriol: 2007, 189(21);7720-32
[PubMed:17720793]
[WorldCat.org]
[DOI]
(P p)
Paul D Straight, Michael A Fischbach, Christopher T Walsh, David Z Rudner, Roberto Kolter
A singular enzymatic megacomplex from Bacillus subtilis.
Proc Natl Acad Sci U S A: 2007, 104(1);305-10
[PubMed:17190806]
[WorldCat.org]
[DOI]
(P p)
Mark Albano, Wiep Klaas Smits, Linh T Y Ho, Barbara Kraigher, Ines Mandic-Mulec, Oscar P Kuipers, David Dubnau
The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions.
J Bacteriol: 2005, 187(6);2010-9
[PubMed:15743949]
[WorldCat.org]
[DOI]
(P p)
M M Nakano, G Zheng, P Zuber
Dual control of sbo-alb operon expression by the Spo0 and ResDE systems of signal transduction under anaerobic conditions in Bacillus subtilis.
J Bacteriol: 2000, 182(11);3274-7
[PubMed:10809710]
[WorldCat.org]
[DOI]
(P p)
G Zheng, R Hehn, P Zuber
Mutational analysis of the sbo-alb locus of Bacillus subtilis: identification of genes required for subtilosin production and immunity.
J Bacteriol: 2000, 182(11);3266-73
[PubMed:10809709]
[WorldCat.org]
[DOI]
(P p)
G Zheng, L Z Yan, J C Vederas, P Zuber
Genes of the sbo-alb locus of Bacillus subtilis are required for production of the antilisterial bacteriocin subtilosin.
J Bacteriol: 1999, 181(23);7346-55
[PubMed:10572140]
[WorldCat.org]
[DOI]
(P p)