LipC

• Description: phospholipase implicated in spore germination
  
  

Gene name	lipC
Synonyms	ycsK
Essential	no
Product	spore coat phospholipase B
Function	spore germination
Function and regulation of this protein in SubtiPathways: Phosphorelay
MW, pI	23 kDa, 5.839
Gene length, protein length	639 bp, 213 aa
Immediate neighbours	kipR, yczI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of lipids, sporulation proteins, germination

This gene is a member of the following regulons

KipR regulon, SigK regulon, TnrA regulon

The gene

Basic information

• Locus tag: BSU04110

Expression

Phenotypes of a mutant

defective in L-alanine-stimulated germination PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: cleaves the fatty acids at the sn-1 and sn-2 positions of phospholipids PubMed

• Protein family: 'GDSL' lipolytic enzyme family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • spore coat PubMed

Database entries

• Structure:

• UniProt: P42969

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • ycsF-ycsG-ycsI-kipI-kipA-kipR-lipC PubMed
  • lipC (according to DBTBS)

• Sigma factor:
  • lipC: SigK PubMed

• Regulation:
  • lipC: expressed four hours after onset of sporulation (GerE) PubMed

• Regulatory mechanism:
  • ycsF: KipR: transcription repression PubMed
  • ycsF: TnrA: transcription activation PubMed
  • GerE: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: