VmlR

• Description: ABC transporter (ATP-binding protein), efflux of antibiotics (virginiamycin M, lincomycin)
  
  

Gene name	vmlR
Synonyms	expZ
Essential	no
Product	antibiotic efflux ABC transporter (ATP-binding protein)
Function	efflux of antibiotics (virginiamycin M, lincomycin)
MW, pI	62 kDa, 6.727
Gene length, protein length	1641 bp, 547 aa
Immediate neighbours	ydgE, ydgF
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics

This gene is a member of the following regulons

RNA switch/ other

The gene

Basic information

• Locus tag: BSU05610

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC transporter family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P39115

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: vmlR PubMed

• Sigma factor: SigA PubMed

• Regulation: induced by virginiamycin M or lincomycin PubMed

• Regulatory mechanism: transcriptional antitermination, details are unknown PubMed

• Additional information:
  • A ncRNA is predicted between vmlR and ydgF PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

Reiko Ohki, Kozue Tateno, Teruaki Takizawa, Toshiko Aiso, Makiko Murata
Transcriptional termination control of a novel ABC transporter gene involved in antibiotic resistance in Bacillus subtilis.
J Bacteriol: 2005, 187(17);5946-54
[PubMed:16109936] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)