Difference between revisions of "PhrF"
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| − | * '''Description:''' [[response regulator aspartate phosphatase]] ([[RapF]]) regulator <br/><br/> | + | * '''Description:''' [[response regulator aspartate phosphatase]] ([[RapF]]) regulator, antagonizes the [[RapF]]-[[ComA]] interaction <br/><br/> |
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=== Additional information=== | === Additional information=== | ||
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| − | ** [[RapF]]-[[PhrF]] {{PubMed|15968044}} | + | ** [[RapF]]-[[PhrF]] {{PubMed|15968044,22215984}} |
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
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* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** PhrF accumulates at high cell density | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
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=References= | =References= | ||
| − | <pubmed>16816200,15968044, 11466295 16091051 </pubmed> | + | <pubmed>16816200,15968044, 11466295 16091051 22215984</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 09:04, 5 January 2012
- Description: response regulator aspartate phosphatase (RapF) regulator, antagonizes the RapF-ComA interaction
| Gene name | phrF |
| Synonyms | ywhI |
| Essential | no |
| Product | phosphatase (RapF) regulator |
| Function | control of ComA activity |
| Interactions involving this protein in SubtInteract: PhrF | |
| MW, pI | 4 kDa, 10.237 |
| Gene length, protein length | 117 bp, 39 aa |
| Immediate neighbours | rapF, ywhH |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
genetic competence, transcription factors and their control, quorum sensing, short peptides
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU37470
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: binds to RapF, this results in the inability of RapF to interact with ComA PubMed
- Protein family: phr family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P71001
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- PhrF accumulates at high cell density
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Melinda D Baker, Matthew B Neiditch
Structural basis of response regulator inhibition by a bacterial anti-activator protein.
PLoS Biol: 2011, 9(12);e1001226
[PubMed:22215984]
[WorldCat.org]
[DOI]
(I p)
Jennifer M Auchtung, Catherine A Lee, Alan D Grossman
Modulation of the ComA-dependent quorum response in Bacillus subtilis by multiple Rap proteins and Phr peptides.
J Bacteriol: 2006, 188(14);5273-85
[PubMed:16816200]
[WorldCat.org]
[DOI]
(P p)
Natalia Comella, Alan D Grossman
Conservation of genes and processes controlled by the quorum response in bacteria: characterization of genes controlled by the quorum-sensing transcription factor ComA in Bacillus subtilis.
Mol Microbiol: 2005, 57(4);1159-74
[PubMed:16091051]
[WorldCat.org]
[DOI]
(P p)
Cristina Bongiorni, Shu Ishikawa, Sophie Stephenson, Naotake Ogasawara, Marta Perego
Synergistic regulation of competence development in Bacillus subtilis by two Rap-Phr systems.
J Bacteriol: 2005, 187(13);4353-61
[PubMed:15968044]
[WorldCat.org]
[DOI]
(P p)
R S McQuade, N Comella, A D Grossman
Control of a family of phosphatase regulatory genes (phr) by the alternate sigma factor sigma-H of Bacillus subtilis.
J Bacteriol: 2001, 183(16);4905-9
[PubMed:11466295]
[WorldCat.org]
[DOI]
(P p)
