Difference between revisions of "MtlD"

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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
**  [[MtlR]]: transcription activation  {{PubMed|20444094}}
 
**  [[MtlR]]: transcription activation  {{PubMed|20444094}}
 +
 
* '''Additional information:'''
 
* '''Additional information:'''
 +
** An [[ncRNA|antisense RNA]] is predicted for ''[[mtlD]]'' {{PubMed|20525796}}
  
 
=Biological materials =
 
=Biological materials =
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=References=
 
=References=
  
<pubmed>12897001, 20444094,10627040 </pubmed>
+
<pubmed>12897001, 20444094,10627040 20525796</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 19:39, 4 May 2011

  • Description: mannitol-1-phosphate 5-dehydrogenase

Gene name mtlD
Synonyms mtlB
Essential no
Product mannitol-1-phosphate 5-dehydrogenase
Function mannitol utilization
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 40 kDa, 6.291
Gene length, protein length 1098 bp, 366 aa
Immediate neighbours mtlF, ycsA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MtlD context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

MtlR regulon

The gene

Basic information

  • Locus tag: BSU03990

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH (according to Swiss-Prot)
  • Protein family: mannitol dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 3H2Z (from Shigella flexneri 2a str. 2457t mutant, 42% identity, 59% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References