Difference between revisions of "LtaS"
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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of lipoteichoic acid | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of lipoteichoic acid | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/ | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_synthesis.html Lipid synthesis]''' |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 74 kDa, 5.202 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 74 kDa, 5.202 | ||
Revision as of 14:14, 7 March 2010
- Description: lipoteichoic acid synthase
| Gene name | ltaS |
| Synonyms | yflE |
| Essential | no |
| Product | major lipoteichoic acid synthase |
| Function | biosynthesis of lipoteichoic acid |
| Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis | |
| MW, pI | 74 kDa, 5.202 |
| Gene length, protein length | 1947 bp, 649 aa |
| Immediate neighbours | nagP, yflD |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: LTA synthase family (according to Swiss-Prot)
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylated on Thr-297 PubMed
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cell membrane (according to Swiss-Prot), extracellular (signal peptide) PubMed
Database entries
- Structure: 2W8D
- UniProt: O34952
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: ltaS (according to DBTBS)
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Kathrin Schirner, Jon Marles-Wright, Richard J Lewis, Jeff Errington
Distinct and essential morphogenic functions for wall- and lipo-teichoic acids in Bacillus subtilis.
EMBO J: 2009, 28(7);830-42
[PubMed:19229300]
[WorldCat.org]
[DOI]
(I p)
Duo Lu, Mirka E Wörmann, Xiaodong Zhang, Olaf Schneewind, Angelika Gründling, Paul S Freemont
Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS.
Proc Natl Acad Sci U S A: 2009, 106(5);1584-9
[PubMed:19168632]
[WorldCat.org]
[DOI]
(I p)
Angelika Gründling, Olaf Schneewind
Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus.
Proc Natl Acad Sci U S A: 2007, 104(20);8478-83
[PubMed:17483484]
[WorldCat.org]
[DOI]
(P p)
