Difference between revisions of "FadA"

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=Expression and regulation=
 
=Expression and regulation=
 
+
* '''Operon:'''
* '''Operon:'''  
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** ''[[fadM]]-[[fadN]]-[[fadA]]-[[fadE]]'' {{PubMed|17189250}}
 +
** ''[[fadN]]-[[fadA]]-[[fadE]]'' {{PubMed|17189250}}
  
 
* '''[[Sigma factor]]:'''  
 
* '''[[Sigma factor]]:'''  
 +
** ''[[fadN]]'': [[SigA]] {{PubMed|17189250}}
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
** repressed in the absence of long-chain fatty acids ([[FadR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/17189250 PubMed]
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** ''[[fadN]]'': induced by long-chain fatty acids ([[FadR]]) {{PubMed|17189250}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
** [[FadR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/17189250 PubMed]
+
** [[FadR]]: transcription repression {{PubMed|17189250}}
 +
** [[SdpR]]: transcription activation {{PubMed|12817086}}
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  
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=References=
 
=References=
  
<pubmed>17189250,17189250, </pubmed>
+
<pubmed>17189250,12817086, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 16:27, 28 December 2009

  • Description: acetyl-CoA C-acyltransferase

Gene name fadA
Synonyms yusK
Essential no
Product acetyl-CoA C-acyltransferase
Function fatty acid degradation
MW, pI 40 kDa, 5.184
Gene length, protein length 1173 bp, 391 aa
Immediate neighbours fadE, fadN
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YusK context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU32830

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA (according to Swiss-Prot)
  • Protein family: thiolase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250] [WorldCat.org] [DOI] (P p)

José E González-Pastor, Errett C Hobbs, Richard Losick
Cannibalism by sporulating bacteria.
Science: 2003, 301(5632);510-3
[PubMed:12817086] [WorldCat.org] [DOI] (I p)