Difference between revisions of "Rok"
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| − | * '''Description:''' repressor of comK <br/><br/> | + | * '''Description:''' repressor of ''[[comK]]'' <br/><br/> |
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' | + | * '''Operon:''' ''rok'' {{PubMed|12354229}} |
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
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=References= | =References= | ||
| − | <pubmed>11849533,15819619,15743949,,17493123,14651647, | + | <pubmed>11849533,15819619,15743949,,17493123,14651647,12354229 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 20:47, 5 October 2009
- Description: repressor of comK
| Gene name | rok |
| Synonyms | ykuW |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of genetic competence |
| MW, pI | 21 kDa, 9.701 |
| Gene length, protein length | 573 bp, 191 aa |
| Immediate neighbours | ykuV, yknT |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU14240
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O34857
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: rok PubMed
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Wiep Klaas Smits, Tran Thu Hoa, Leendert W Hamoen, Oscar P Kuipers, David Dubnau
Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein.
Mol Microbiol: 2007, 64(2);368-81
[PubMed:17493123]
[WorldCat.org]
[DOI]
(P p)
Hédia Maamar, David Dubnau
Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop.
Mol Microbiol: 2005, 56(3);615-24
[PubMed:15819619]
[WorldCat.org]
[DOI]
(P p)
Mark Albano, Wiep Klaas Smits, Linh T Y Ho, Barbara Kraigher, Ines Mandic-Mulec, Oscar P Kuipers, David Dubnau
The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions.
J Bacteriol: 2005, 187(6);2010-9
[PubMed:15743949]
[WorldCat.org]
[DOI]
(P p)
Virginie Molle, Masaya Fujita, Shane T Jensen, Patrick Eichenberger, José E González-Pastor, Jun S Liu, Richard Losick
The Spo0A regulon of Bacillus subtilis.
Mol Microbiol: 2003, 50(5);1683-701
[PubMed:14651647]
[WorldCat.org]
[DOI]
(P p)
Noel Baichoo, Tao Wang, Rick Ye, John D Helmann
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon.
Mol Microbiol: 2002, 45(6);1613-29
[PubMed:12354229]
[WorldCat.org]
[DOI]
(P p)
Tran Thu Hoa, Pablo Tortosa, Mark Albano, David Dubnau
Rok (YkuW) regulates genetic competence in Bacillus subtilis by directly repressing comK.
Mol Microbiol: 2002, 43(1);15-26
[PubMed:11849533]
[WorldCat.org]
[DOI]
(P p)
