Difference between revisions of "NtdA"
| Line 88: | Line 88: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' | + | * '''Operon:''' ''[[ntdA]]-[[ntdB]]-[[ntdC]]-[[glcP]]'' {{PubMed|17056753}} |
| − | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|14612444}} |
| − | * '''Regulation:''' | + | * '''Regulation:''' induced by 3,3'-neotrehalosadiamine ([[NtdR]]) {{PubMed|14612444}} |
| − | * '''Regulatory mechanism:''' | + | * '''Regulatory mechanism:''' [[NtdR]]: positive regulator {{PubMed|14612444}} |
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 118: | Line 118: | ||
=References= | =References= | ||
| − | <pubmed>19087206,19342798,, | + | <pubmed>19087206,19342798,17056753 ,14612444 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 18:21, 26 July 2009
- Description: synthesis of the antibiotic neotrehalosadiamine
| Gene name | ntdA |
| Synonyms | yhjL |
| Essential | no |
| Product | sugar aminotransferase |
| Function | synthesis of the antibiotic neotrehalosadiamine |
| MW, pI | 49 kDa, 5.971 |
| Gene length, protein length | 1323 bp, 441 aa |
| Immediate neighbours | ntdB, ntdR |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU10550
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: degT/dnrJ/eryC1 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O07566
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
K E van Straaten, D M Langill, D R J Palmer, D A R Sanders
Purification, crystallization and preliminary X-ray analysis of NtdA, a putative pyridoxal phosphate-dependent aminotransferase from Bacillus subtilis.
Acta Crystallogr Sect F Struct Biol Cryst Commun: 2009, 65(Pt 4);426-9
[PubMed:19342798]
[WorldCat.org]
[DOI]
(I p)
Takashi Inaoka, Takenori Satomura, Yasutaro Fujita, Kozo Ochi
Novel gene regulation mediated by overproduction of secondary metabolite neotrehalosadiamine in Bacillus subtilis.
FEMS Microbiol Lett: 2009, 291(2);151-6
[PubMed:19087206]
[WorldCat.org]
[DOI]
(I p)
Takashi Inaoka, Kozo Ochi
Glucose uptake pathway-specific regulation of synthesis of neotrehalosadiamine, a novel autoinducer produced in Bacillus subtilis.
J Bacteriol: 2007, 189(1);65-75
[PubMed:17056753]
[WorldCat.org]
[DOI]
(P p)
Takashi Inaoka, Kosaku Takahashi, Hiroshi Yada, Mitsuru Yoshida, Kozo Ochi
RNA polymerase mutation activates the production of a dormant antibiotic 3,3'-neotrehalosadiamine via an autoinduction mechanism in Bacillus subtilis.
J Biol Chem: 2004, 279(5);3885-92
[PubMed:14612444]
[WorldCat.org]
[DOI]
(P p)
