Difference between revisions of "TrxA"
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* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2GZZ 2GZZ] (oxidized form), [http://www.rcsb.org/pdb/explore.do?structureId=2GZY 2GZY] (reduced form), [http://www.rcsb.org/pdb/explore.do?structureId=2IPA 2IPA] (TrxA-ArsC-complex) | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2GZZ 2GZZ] (oxidized form), [http://www.rcsb.org/pdb/explore.do?structureId=2GZY 2GZY] (reduced form), [http://www.rcsb.org/pdb/explore.do?structureId=2IPA 2IPA] (TrxA-ArsC-complex) | ||
| − | * ''' | + | * '''UniProt:''' [http://www.uniprot.org/uniprot/P14949 P14949] |
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU28500] | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU28500] | ||
Revision as of 13:59, 20 July 2009
- Description: antioxidative action by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange
| Gene name | trxA |
| Synonyms | trx |
| Essential | yes PubMed |
| Product | thioredoxin |
| Function | protection of proteins against oxidative damage |
| MW, pI | 11 kDa, 4.308 |
| Gene length, protein length | 312 bp, 104 aa |
| Immediate neighbours | uvrC, abf2 |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU28500
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: thioredoxin family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P14949
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation: induced by stress (SigB) [http://www.ncbi.nlm.nih.gov/pubmed/11544224 PubMed; Regulation by Spx in response to diamide stress
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
