trpS
168
tryptophanyl-tRNA synthetase
locus
BSU_11420
Molecular weight
37.04 kDa
pI
6.54
function
translation
product
tryptophanyl-tRNA synthetase
essential
yes
ec
6.1.1.2
synonyms
trpS
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0180 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,218,113 1,219,105
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + L-tryptophan + tRNATrp --> AMP + diphosphate + H+ + L-tryptophanyl-tRNATrp (according to UniProt)
Protein family
[wiki|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|3PRH] (Val144Pro mutant) [Pubmed|21224416]
[PDB|1BM2] (complex with tryptophan, ''Geobacillus stearothermophilus'')
[PDB|1MAW] (complex with ATP, ''Geobacillus stearothermophilus'')
[AF|P21656]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|0D6CB84E74C32B0384BDC7740AA317EDEC5D60B6|trpS]
description
[Pubmed|8915527]
regulation
induced by tryptophan limitation ([protein|search|T-box]) [Pubmed|8915527]
additional information
A [wiki|ncRNA] is predicted between [gene|0D6CB84E74C32B0384BDC7740AA317EDEC5D60B6|trpS] and [gene|302DFA46D73E18C4663468ED6033C55056744475|oppA] [PubMed|20525796]
the [wiki|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
References
Reviews
Original Publications
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Time of last update: 2025-03-17 04:19:51
Author of last update: Melvin.boenninger