sigI
168

RNA polymerase sigma factor SigI

Locus

BSU_13450

Molecular weight

29.04 kDa

Isoelectric point

8.31

Protein length

251 aaSequenceBlast

Gene length

756 bpSequenceBlast

Function

control of a class of heat shock genes

Product

RNA polymerase sigma factor SigI

Essential

Synonyms

sigI, ykoZ

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1191 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,411,892 1,412,647

Phenotypes of a mutant

temperature-sensitive growth on agar plates PubMed

a cwlO sigI mutant is not viable, due to lack of expression of lytE PubMed

a sigI ponA double mutant is not viable due to its inability to repair gaps in the peptidoglycan mesh PubMed, the growth defect can be suppressed by reduced fatty acid synthesis (mutations in accA, accB, accC, accD or downregulation of the FapR regulon due to specific mutations in fapR) PubMed

The protein

Protein family

Sigma-70 factor family (according to UniProt)

Structure

6IVU (PDB) (from Hungateiclostridium thermocellum, corresponds to aa 141 ... 245, 38% identity) PubMed

O31654 (AlphaFold)

Localization

information on binding sites can be found in the PRODORIC2 database

Additional information

overexpression of SigI suppresses ''mreB mreBH mbl'' mutants PubMed

Expression and Regulation

Operons