padR
168
repressor of [gene|1E0BA378F14ADF03D613DA3BF3241C1ADE75075E|yveF]-[gene|1F56C126099E1D5241069E06477F277C12B20C58|yveG]-[gene|ECA64CB1E4BF8B6B0854B1B63C9E85A519059C6C|padC], induction occurs by binding of phenolic acids,stress response
locus
BSU_08340
Molecular weight
21.08 kDa
pI
7.23
function
regulation of the phenolic acid stress response
product
transcriptional repressor
essential
no
synonyms
padR, yfiO
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1695 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
909,198 909,746
The protein
[wiki|Domains]
N-terminal winged helix-turn-helix (wHTH) domain (NTD) [pubmed|29136175]
C-terminal homodimerization domain (CTD) [pubmed|29136175]
Structure
[PDB|5X12] (PadR) [pubmed|29136175]
[PDB|5X11] (complex with dsDNA) [pubmed|29136175]
[PDB|5X13] (complex with p-coumaric acid) [pubmed|29136175]
[AF|P94443]
Effectors of protein activity
phenolic acid acts as molecular inducer and releases PadR from the'' [gene|1E0BA378F14ADF03D613DA3BF3241C1ADE75075E|yveF]-[gene|1F56C126099E1D5241069E06477F277C12B20C58|yveG]-[gene|ECA64CB1E4BF8B6B0854B1B63C9E85A519059C6C|padC]'' promoter [Pubmed|18326577]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|A7824EACE0C109C676A374FD21F59D671B703305|padR]
description
[pubmed|22383849]
regulation
weak constitutive expression
Biological materials
Mutant
MGNA-C303 (yfiO::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2301 NBRP B. subtilis, Japan]
BKE08340 ([gene|A7824EACE0C109C676A374FD21F59D671B703305|padR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE08340 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCTATCCTCCGTGTCTG, downstream forward: _UP4_TAACCGCAGTTCAGGCTGCA
BKK08340 ([gene|A7824EACE0C109C676A374FD21F59D671B703305|padR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK08340 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCTATCCTCCGTGTCTG, downstream forward: _UP4_TAACCGCAGTTCAGGCTGCA
References
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Time of last update: 2025-01-26 15:48:42
Author of last update: Jstuelk