czrA
168
transcriptional repressor ([wiki|ArsR family]), [gene|5BC6B02770E74FF6D453742832574A87BB2369B8|cadA] and [gene|7FB5BCC16D688465A820F436F657C49625257884|czcD]
locus
BSU_19120
Molecular weight
12.24 kDa
pI
5.72
function
regulation of resistance against toxic metal cations
product
transcriptional repressor ([wiki|ArsR family])
essential
no
synonyms
czrA, yozA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0640 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,084,786 2,085,109
The protein
Protein family
[wiki|ArsR family]
[wiki|Domains]
[wiki|HTH arsR-type domain] (aa 14-107) (according to UniProt)
Structure
[PDB|1R1U] (the apo-repressor from ''Staph. aureus'', 49% identity, 82% similarity) [Pubmed|14568530]
[PDB|1R1V] (the Zn(II) form from ''Staph. aureus'', 49% identity, 82% similarity) [Pubmed|14568530]
[PDB|2KJB] (the DNA-bound form from ''Staph. aureus'', 49% identity, 82% similarity) [Pubmed|19822742]
[AF|O31844]
Effectors of protein activity
DNA-binding activity of CzrA is inactivated by high concentrations of toxic metal ions (induction)
Expression and Regulation
Operons
genes
[gene|6FB1865734C4DE7BE19D3D1A7E0C687B6D7094E1|czrA]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-B412 (yozA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1411 NBRP B. subtilis, Japan]
BKE19120 ([gene|6FB1865734C4DE7BE19D3D1A7E0C687B6D7094E1|czrA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE19120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTATCACCTTTCTTT, downstream forward: _UP4_TGAAAAAGACATCCTTGCTT
BKK19120 ([gene|6FB1865734C4DE7BE19D3D1A7E0C687B6D7094E1|czrA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK19120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTATCACCTTTCTTT, downstream forward: _UP4_TGAAAAAGACATCCTTGCTT
References
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Time of last update: 2025-04-03 21:23:30
Author of last update: Melvin.boenninger