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bkdR
168
transcriptional activator of the [gene|1CFF7202AC6078B6BAD1253F77FD4FE227C046DB|ptb]-[gene|A52E50104B18D0A8518218C52D9CC36FDDB29AAF|bcd]-[gene|8E08A0333E4EC89003DA3C1DD8DCD39CDDC8624C|buk]-[gene|1FD06CB6E81C920EFC656DBE2A13D68B1AA68872|lpdV]-[gene|9F298088C0A9EB7FE140C935AFC9243C6D4DE8AE|bkdAA]-[gene|A024921961A786294199EA12E04456C890ED8D8C|bkdAB]-[gene|262C9FD20C7A70B6F1FEB57735FA800F38EAB25A|bkdB] operon
Molecular weight
77.75 kDa
function
regulation of branched-chain amino acid utilization
product
transcriptional activator (for [protein|1118A21CC581B0470EC6E7C178F2523CDCA70F93|sigL]-dependent promoter)
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
2,504,789 2,506,867
Phenotypes of a mutant
cold-sensitive [pubmed|16585774]
The protein
Protein family
[wiki|Transcription factors activating transcription at SigL-dependent promoters]
[wiki|Domains]
2 [wiki|PAS domain]s (aa 115-185, aa 234-305) (according to UniProt)
[wiki|Sigma-54 factor interaction domain] (aa 368-598) (according to UniProt)
Structure
[PDB|1OJL] (ZraR from Salmonella typhimurium, C-terminal interaction domain, corresponds to aa 368 ... 683 of BkdR, 41% identity) [pubmed|16005641]
[AF|P54529]
Expression and Regulation
Operons
genes
[gene|4CEBD81F485DD0B660E297FFC34A0F5270652184|bkdR]
description
[Pubmed|12823818]
regulation
repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|10094682]
regulatory mechanism
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|10094682], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
[gene|4CEBD81F485DD0B660E297FFC34A0F5270652184|bkdR]
2025-03-15 01:06:47
ghost
62
0e1bfd55a8b3791b028825e69c410ed676bb4d78
EDEAE051F5DD0CBC67A449638887F64DE1A2BE4D
Biological materials
Mutant
MGNA-C375 (yqiR::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2373 NBRP B. subtilis, Japan]
1A913 ( ''bkdR''::''kan''), [Pubmed|16585774], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A913&Search=1A913 BGSC] and in [wiki|Jörg Stülke]'s lab
BKE24100 ([gene|4CEBD81F485DD0B660E297FFC34A0F5270652184|bkdR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24100 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCCGATACCCCTTTGTA, downstream forward: _UP4_TAATTTGCAGAATAAACGCA
BKK24100 ([gene|4CEBD81F485DD0B660E297FFC34A0F5270652184|bkdR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24100 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCCGATACCCCTTTGTA, downstream forward: _UP4_TAATTTGCAGAATAAACGCA
References
16585774,10094682,23123912,12823818,21906631,16005641
