adhR
168
transcriptional activator ([wiki|MerR family]) of [gene|352544F3E79943E94E28A6EB5F4C543B529A02D1|adhA]-[gene|0960F1856A81237DBA6AF1FAF36172A63ECBE2D5|yraA], responsive to formaldehyde and methylglyoxal
locus
BSU_27000
Molecular weight
16.30 kDa
pI
9.64
function
regulation of the protective response to formaldehyde and methylglyoxal
product
transcriptional activator ([wiki|MerR family])
essential
no
synonyms
adhR, yraB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0789 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,755,382 → 2,755,804
The protein
Protein family
[wiki|MerR family]
[wiki|Domains]
[wiki|HTH merR-type domain] (aa 1-69) (according to UniProt)
Structure
[PDB|3GP4] (from Listeria monocytogenes, 47% identity)
[AF|O06008]
Modification
activity probably redox-controlled via thiol-(S)-alkylation at Cys-52 by aldehydes [Pubmed|19170879]
[wiki|Localization]
cytoplasmic
Expression and Regulation
Operons
genes
[gene|B24BA6ABCAF7325EC5F8B2655CA182FFC23395FD|adhR]
description
[pubmed|22383849]
Biological materials
Mutant
MGNA-A238 (yraB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/238 NBRP B. subtilis, Japan]
BKE27000 (Δ[gene|B24BA6ABCAF7325EC5F8B2655CA182FFC23395FD|adhR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCTTCACCTCTCTAT, downstream forward: _UP4_TAGCATTCTTTGCGTGTGAA
BKK27000 (Δ[gene|B24BA6ABCAF7325EC5F8B2655CA182FFC23395FD|adhR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCTTCACCTCTCTAT, downstream forward: _UP4_TAGCATTCTTTGCGTGTGAA
labs
[wiki|Haike Antelmann],University of Greifswald, Germany
References
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Time of last update: 2025-04-14 17:06:27
Author of last update: Melvin.boenninger