nrdR
168
negative regulator of transcription of the ribonucleotide reductase nrd operon
locus
BSU_29000
Molecular weight
17.77 kDa
pI
8.05
function
control of ribonucleotide reductase expression
product
transcription repressor of the ribonucleotide reductase nrd operon
essential
no
synonyms
nrdR, ytcG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1327 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,965,681 → 2,966,139
The protein
Protein family
nrdR family (single member, according to UniProt)
Structure
[PDB|7P37] (from Streptomyces coelicolor, ATP-loaded NrdR dodecamer, 46% identity) [pubmed|35577776]
[PDB|7P3F] (from Streptomyces coelicolor, dATP/ATP-loaded NrdR tetramer bound to its cognate DNA, 46% identity) [pubmed|35577776]
[PDB|7P3Q] (from Streptomyces coelicolor, dATP/ATP-loaded NrdR octamer, 46% identity) [pubmed|35577776]
[AF|Q45549]
Expression and Regulation
Operons
genes
[gene|FD4E988BB73F6476CCEA4C521F343D6F8CBA457F|nrdR]
description
[Pubmed|9387221]
regulation
constitutively expressed [Pubmed|27920297]
additional information
the terminator is [protein|search|NusA]-dependent [ http://www.nature.com/articles/nmicrobiol20157 Reference]
Biological materials
Mutant
MGNA-A123 (ytcG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/123 NBRP B. subtilis, Japan]
BKE29000 (Δ[gene|FD4E988BB73F6476CCEA4C521F343D6F8CBA457F|nrdR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATAAAATCAGCTCCCAAC, downstream forward: _UP4_TAAAAGAGCTAAGAGGATTC
BKK29000 (Δ[gene|FD4E988BB73F6476CCEA4C521F343D6F8CBA457F|nrdR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATAAAATCAGCTCCCAAC, downstream forward: _UP4_TAAAAGAGCTAAGAGGATTC
References
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Time of last update: 2025-04-01 17:53:35
Author of last update: Jstuelk