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ricA
168
subunit of the regulatory iron-sulfur containing [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex, required for handing over of [protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] to [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] to facilitate maturation of polycistronic mRNAs, antagonist of biofilm repression by [protein|5A6FBAE6553343092862CB79E150F934978C32A9|sinR], control of the [wiki|phosphorelay]
Molecular weight
16.02 kDa
function
control of [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] activity, see [wiki|Targets of the Y complex]
product
subunit of the regulatory iron-sulfur containing [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
1,774,374 → 1,774,805
Phenotypes of a mutant
strongly reduced [wiki|genetic competence], strongly reduced [wiki|sporulation] [Pubmed|23490197]
defective in [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y]-mediated maturation of polycistronic mRNAs, see [wiki|Targets of the Y complex] [pubmed|29794222]
defective in [category|SW.4.1.4|Swarming] motility (prolonged period of immotility prior to [category|SW.4.1.4|Swarming]) [pubmed|35638827]
The protein
Catalyzed reaction/ biological activity
the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex acts as specificity factor for [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y]-dependent processing of polycistronic mRNAs, see [wiki|Targets of the Y complex] [pubmed|29794222]
the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex stimulates [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A] phosphorylation in the [category|SW.4.2.2|phosphorelay] [pubmed|27501195]
[wiki|Cofactors]
one 4Fe-4S cluster (contributes to the co-ordination of the cluster (with [protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF] and [protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT])) [pubmed|31530674]
Structure
[PDB|6PRH] (the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]dimer) [pubmed|31530674]
[PDB|6PRK] (the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF] complex) [pubmed|31530674]
[AF|O31779]
[wiki|Localization]
cytoplasm [pubmed|35326384,27501195]
Expression and Regulation
Operons
genes
[gene|7C9F99FF1BCDB0E1CFB0AFE959C7F16A99562E18|ymcB]-[gene|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]
description
[Pubmed|22383849]
[gene|7C9F99FF1BCDB0E1CFB0AFE959C7F16A99562E18|ymcB]→[gene|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]
2024-11-09 03:22:39
Jstuelk
113
3e3a6f134a159c836765f56a2b8ca1ad0486f543
499370F86D29FCA5A0F1CC6BF69F2E56ADD25D11
Biological materials
Mutant
BKE17020 (Δ[gene|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE17020 BGSC] and in [wiki|Jörg Stülke]'s lab, [Pubmed|28189581], upstream reverse: _UP1_GTCTTTTTTTGAGTAGAGCG, downstream forward: _UP4_TAAACACGGTGCCTTTACAG
BKK17020 (Δ[gene|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK17020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTCTTTTTTTGAGTAGAGCG, downstream forward: _UP4_TAAACACGGTGCCTTTACAG
References
Reviews
32061882,32156829,32156813,35638784 Original Publications
15661000,23490197,15175311,26434553,28295778,27501195,29794222,30265683,31530674,35326384,35638827,37555678
