sivA
168
inhibitor of [protein|B29CAD04FB89ACC482EFCD29D50EDDA19145CAA2|kinA] autophosphorylation, and subsequently of entry into [wiki|sporulation]
locus
BSU_37800
Molecular weight
16.55 kDa
pI
7.18
function
control of entry into [wiki|sporulation] via the [wiki|phosphorelay]
product
inhibitor of [protein|B29CAD04FB89ACC482EFCD29D50EDDA19145CAA2|kinA] autophosphorylation
essential
no
synonyms
sivA, yweA, ipa-74d
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
3,882,191 → 3,882,655
Phenotypes of a mutant
the'' [gene|E5E2994D96FCECEE75E15136A08308C7B6C1C183|sivA] [gene|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|bslA]'' double mutant exhibits a more severe loss of repellency of the biofilm surface as compared to the ''[gene|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|bslA]'' mutant [Pubmed|22571672]
The protein
Catalyzed reaction/ biological activity
inhibits [protein|B29CAD04FB89ACC482EFCD29D50EDDA19145CAA2|kinA] autophophorylation [Pubmed|23335417]
Protein family
BslA/BslB family (with [protein|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|bslA], according to UniProt)
Structure
[PDB|5MKD] (aa 31 ... 155) [pubmed|37903266]
[AF|P39632]
Paralogous protein(s)
[protein|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|bslA]
[wiki|Localization]
membrane (according to Swiss-Prot)
extracellular (signal peptide) [Pubmed|18957862]
Expression and Regulation
Operons
genes
[gene|E5E2994D96FCECEE75E15136A08308C7B6C1C183|sivA]
description
[Pubmed|12823818]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
Biological materials
Mutant
MGNA-B238 (yweA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1237 NBRP B. subtilis, Japan]
BKE37800 (Δ[gene|E5E2994D96FCECEE75E15136A08308C7B6C1C183|sivA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE37800 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGACATTTCCCCCTAATT, downstream forward: _UP4_TAATCGATAGATTTGTAGTC
BKK37800 (Δ[gene|E5E2994D96FCECEE75E15136A08308C7B6C1C183|sivA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK37800 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGACATTTCCCCCTAATT, downstream forward: _UP4_TAATCGATAGATTTGTAGTC
References
Page visits: 3494
Time of last update: 2025-01-07 21:44:22
Author of last update: Jstuelk