spoIIB
168
spatial and temporal regulation of the dissolution of septal peptidoglycan during engulfment
locus
BSU_28060
Molecular weight
35.77 kDa
pI
4.8
function
spore morphogenesis
product
facilitator of septal dissolution
essential
no
ec
null
synonyms
spoIIB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5816 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,863,294 → 2,864,292
Phenotypes of a mutant
reduced sporulation frequency (10 to 20-fold) [pubmed|36066101]
slow and inefficient spore engulfment [pubmed|36066101]
The protein
Catalyzed reaction/ biological activity
required for efficient localization of the [protein|AAC4BF6FA80115AB90D2B161C1D5383625953616|spoIID]-[protein|14852D54F8B7344AA80D535F8EBBCE11E2B859CF|spoIIM]-[protein|C9817A54C8E72193280E393D7BD3375BD1751738|spoIIP] complex to the septal membrane [pubmed|36066101]
[wiki|Domains]
SPOR domain (aa 175-250) (according to UniProt)
Structure
[AF|P37575]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|D98D61CA651AAA415386B1B2B41562E5CF77DEF1|spoIIB]
description
[Pubmed|12107147]
regulation
expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]
sigma factors
[protein|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV]: sigma factor, in [regulon|protein:D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV regulon]
Biological materials
Mutant
BKE28060 (Δ[gene|D98D61CA651AAA415386B1B2B41562E5CF77DEF1|spoIIB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE28060 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATTCCGCTTCCTCCCTTC, downstream forward: _UP4_TAAGAGATAGTGCCCTGAGC
BKK28060 (Δ[gene|D98D61CA651AAA415386B1B2B41562E5CF77DEF1|spoIIB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK28060 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATTCCGCTTCCTCCCTTC, downstream forward: _UP4_TAAGAGATAGTGCCCTGAGC
References
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Time of last update: 2025-04-08 12:48:26
Author of last update: Jstuelk