yngA
168
flippase, transports the glucose-phosphate moiety of C55-P-Glc across the membrane
locus
BSU_18170
Molecular weight
16.52 kDa
pI
9.15
function
glycosylation of teichoic acids
product
flippase for teichoic acid glycosylation
essential
no
synonyms
yngA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2246 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,946,249 → 1,946,695
The protein
Protein family
GtrA family (with [protein|FD30C4E458E63E8D6A932B351D4224F1AACD4B1B|gtcA], according to UniProt)
Structure
[PDB|5MLZ] (from Pyrococcus furiosus, 20% identity) [pubmed|28743912]
[AF|O31821]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|CBCBF948979D9D63CBA86A9ED865E43B1F85A0AD|yngA]-[gene|69C5D9EF7ED43BCAB7A9D6148EDD323CE72F8E3D|yngB]-[gene|289828D37CF5422908316ED2EF1AEAE76F84161D|uptA]
description
[Pubmed|20512483]
regulation
expression during spore [wiki|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
expressed under anaerobic conditions ([protein|706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ]) [pubmed|33556370]
regulatory mechanism
[protein|706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ]: activation, [Pubmed|20512483], in [regulon|protein:706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ regulon]
Biological materials
Mutant
MGNA-B395 (yngA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1394 NBRP B. subtilis, Japan]
BKE18170 (Δ[gene|CBCBF948979D9D63CBA86A9ED865E43B1F85A0AD|yngA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE18170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTTGTTGATATGGATT, downstream forward: _UP4_ATACAGGATCAGGAGTGAAG
BKK18170 (Δ[gene|CBCBF948979D9D63CBA86A9ED865E43B1F85A0AD|yngA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK18170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTTGTTGATATGGATT, downstream forward: _UP4_ATACAGGATCAGGAGTGAAG
References
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Time of last update: 2025-03-12 21:32:24
Author of last update: Jstuelk