yrvJ
168
secreted N-acetylmuramoyl-L-alanine amidase, contributes to septal peptidoglycan hydrolysis, required for efficient spore engulfment
locus
BSU_27580
Molecular weight
55.33 kDa
pI
5.19
function
cell wall metabolism
product
peptidoglycan hydrolase
essential
no
ec
3.5.1.28
synonyms
yrvJ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3103 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,818,494 → 2,820,050
The protein
Catalyzed reaction/ biological activity
Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides (according to UniProt)
Protein family
[wiki|N-acetylmuramoyl-L-alanine amidase 3 family] (according to UniProt)
[wiki|Domains]
contains an amidase_3 domain (like [protein|5CDF32B0E78F01C696364555E3F0BC8DF2AA2089|cwlC], [protein|B09FB626274B81F00A4FB42D188E089095343182|cwlD], [protein|6A21293823151C6980BF52B31A4B249A8440F2E1|lytC], [protein|0AD75864794E597AA9160969ADE6FE0C7ED07B9F|yqiI])
[wiki|MurNAc-LAA domain] (aa 346-514) (according to UniProt)
4 [wiki|SH3b domain]s (aa 29-92, aa 102-164, aa 181-243, aa 258-320) (according to UniProt)
Structure
[AF|O32041]
Expression and Regulation
Operons
Biological materials
Mutant
BKE27580 (Δ[gene|BE34A9CE3AF99E8880FC24E34E5D79A1627260AE|yrvJ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27580 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTGTCCTCCTTTCTGA, downstream forward: _UP4_TAAAAAAAGCTGCCTTTTGG
BKK27580 (Δ[gene|BE34A9CE3AF99E8880FC24E34E5D79A1627260AE|yrvJ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27580 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTGTCCTCCTTTCTGA, downstream forward: _UP4_TAAAAAAAGCTGCCTTTTGG
References
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Time of last update: 2025-02-16 16:17:37
Author of last update: Jstuelk