ahpA
168
alkyl hydroperoxide reductase
locus
BSU_14220
Molecular weight
20.30 kDa
pI
4.49
function
protection against peroxide stress
product
alkyl hydroperoxide reductase
essential
no
synonyms
ahpA, ykuU
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0450 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,492,261 → 1,492,803
The protein
Catalyzed reaction/ biological activity
[protein]-dithiol + hydroperoxide --> [protein]-disulfide + alcohol + H2O (according to UniProt)
Protein family
[wiki|peroxiredoxin family] (according to UniProt)
[wiki|Domains]
[wiki|Thioredoxin domain] (aa 4-165) (according to UniProt)
Structure
[PDB|4XCS] (human peroxiredoxin, 48% identity)
[AF|O34564]
Paralogous protein(s)
[protein|D0982500E52577D52FADF775C0E512A4B9657B79|ahpC]
Expression and Regulation
Operons
genes
[gene|B283B702D917E310130BC33A40BF6A5853C3D4C1|ahpA]-[gene|398E6FAC317D9BD81FB80A7CC9DF1CC757F2FA98|ahpT]
description
[Pubmed|20817675]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
Biological materials
Mutant
GP1729 [gene|search|ahpAT]::kan trpC2 available at Jörg Stülkes lab
MGNA-B343 (ykuU::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1342 NBRP B. subtilis, Japan]
BKE14220 (Δ[gene|B283B702D917E310130BC33A40BF6A5853C3D4C1|ahpA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTATCCCTCCAATTT, downstream forward: _UP4_TAATTCTTTCCAAGAACGAA
BKK14220 (Δ[gene|B283B702D917E310130BC33A40BF6A5853C3D4C1|ahpA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTATCCCTCCAATTT, downstream forward: _UP4_TAATTCTTTCCAAGAACGAA
References
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Time of last update: 2025-04-05 10:21:18
Author of last update: Melvin.boenninger