xylR
168
transcriptional repressor of the [gene|24829427B4518FE67038F194B54D4AAFAC64EF19|xylA]-[gene|search|xylB ]and [gene|F92925E2FDCFE6DDA3E87C7B541FE6A6CE5AABB8|xynP]-[gene|search|xynB ]operons
locus
BSU_17590
Molecular weight
38.29 kDa
pI
5.82
function
regulation of xylan and xylose utilization
product
transcriptional repressor
essential
no
synonyms
xylR
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1940 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,890,512 → 1,891,564
The protein
Catalyzed reaction/ biological activity
transcription repression of the ''[gene|24829427B4518FE67038F194B54D4AAFAC64EF19|xylA]-[gene|F417A5B46CC7FC69DC8606A46D1AD5E41FA35B13|xylB]'' and the ''[gene|F92925E2FDCFE6DDA3E87C7B541FE6A6CE5AABB8|xynP]-[gene|19CD9BF216953613CD2E0DFB99D4C6E92AAFAE5D|xynB]'' operons
Protein family
ROK (NagC/XylR) family (with [protein|EB6DE119E6FB18413DB2C2B62B114FB787164F74|gmuE] and [protein|8E10A8B566BC25CBDDEF1503656A4234FD29ACB8|glcK], according to UniProt)
Structure
[PDB|5F7R] (Rok from Listeria monocytogenes, 28% identity) [pubmed|27819654]
[AF|P94490]
Effectors of protein activity
inducer: xylose
Paralogous protein(s)
[protein|8E10A8B566BC25CBDDEF1503656A4234FD29ACB8|glcK]
Expression and Regulation
Operons
genes
[gene|AF4395D134485290F4AA307B48494FED39E52CD7|xylR]
description
[pubmed|22383849]
Biological materials
Mutant
GP270 (erm), GP1302 (aphA3), available in the [wiki|Stülke] lab
BKE17590 (Δ[gene|AF4395D134485290F4AA307B48494FED39E52CD7|xylR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE17590 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTTCATCCACTCCATTTG, downstream forward: _UP4_TAATTTTTTATGGAATGGAC
BKK17590 (Δ[gene|AF4395D134485290F4AA307B48494FED39E52CD7|xylR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK17590 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTTCATCCACTCCATTTG, downstream forward: _UP4_TAATTTTTTATGGAATGGAC
labs
[wiki|Wolfgang Hillen], Erlangen University, Germany
References
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Time of last update: 2025-04-07 08:59:14
Author of last update: Melvin.boenninger