Explore the novel features of the upcoming release of in its beta version,
SubtiWiki v5! It features genomic conservation, interaction of proteins with metabolites, dedicated metabolite pages, and much more!
Check the pages for
MntR and
manganese!
mhqR
168
[wiki|MarR family ]transcriptional repressor of [gene|0E2B1914A040666BAF042C0BE3F468144E1F1E06|azoR2], [gene|7334017333600B876030056BE9247AD4E8996A1D|mhqA], [gene|43CD556065D2EF14365C78E014B7B2051CA0C78F|mhqD]-[gene|A1CB3DCF2EC78B9B0585CA6AC6F5BB37B8AF0208|mhqE]and [gene|A0842DD5F1B13AC15C95F18751E7836DF31B262A|mhqN]-[gene|ACAFB2072E74CC059B492A31EF492028B96C569F|mhqO]-[gene|search|mhqP ]expression
Molecular weight
16.43 kDa
function
regulation of resistance to quinones and diamide
product
[wiki|MarR family ]transcriptional repressor
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
1,433,199 1,433,636
Phenotypes of a mutant
resistant to quinones and diamide
inactivation of ''mhqR'' predisposes cells to grow without a wall (due to protection from oxidative stress) [Pubmed|26051891]
The protein
[wiki|Domains]
[wiki|HTH marR-type domain] (aa 5-137) (according to UniProt)
Structure
[PDB|3GFJ] (from Sulfolobus tokodaii, 26% identity) [pubmed|19509310]
[AF|O31672]
Paralogous protein(s)
[protein|A703CA58365926CFE6BFC1C4A0B1DA22C67C85AC|ykoM]
Additional information
Binding site: tATCTcgaAtTCgAGATaaaa [Pubmed|17725564]
information on binding sites can be found in the [http://www.prodoric2.de/detail.php?acc=MX000225 PRODORIC2 database]
Expression and Regulation
Operons
genes
[gene|997B828A99D6D8460712C18ED0CE566B285C22DC|mhqR]
description
[Pubmed|22383849]
[gene|997B828A99D6D8460712C18ED0CE566B285C22DC|mhqR]
2025-03-17 13:11:00
ghost
68
1216743de6d486febda3418fb3b1da6275834b2c
6DF15A74CE435FAF05CE6FC4F5E2104ADE7DCA09
Biological materials
Mutant
BKE13670 ([gene|997B828A99D6D8460712C18ED0CE566B285C22DC|mhqR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE13670 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCTCAATCATCCTTTT, downstream forward: _UP4_TAAAAAAAGGAAGCCTGATA
BKK13670 ([gene|997B828A99D6D8460712C18ED0CE566B285C22DC|mhqR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK13670 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCTCAATCATCCTTTT, downstream forward: _UP4_TAAAAAAAGGAAGCCTGATA
labs
[wiki|Haike Antelmann],Free University of Berlin, Germany
References
18282125,26051891,17725564,22383849,27965289,19509310,34097790
