yodB
168
[wiki|MarR family|MarR/DUF24 family] transcription repressor of [gene|CFFFFE96FB7AEEF7190F81332369F0A6834C34A4|azoR1], [gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|search|catE ]and [gene|search|yodC ]expression
locus
BSU_19540
Molecular weight
12.71 kDa
pI
4.74
function
regulation of quinone and diamide detoxification
product
[wiki|MarR family|MarR/DUF24 family] transcription repressor
essential
no
synonyms
yodB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1733 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,127,345 2,127,683
Phenotypes of a mutant
increased resistance to catechol, quinones and diamide [Pubmed|20639328]
The protein
Protein family
[wiki|MarR family|MarR/DUF24 family]
[wiki|Domains]
[wiki|HTH hxlR-type domain] (aa 6-105) (according to UniProt)
Structure
[PDB|5HS7] (reduced form) [Pubmed|27531959]
[PDB|5HS8] (diamide-treated form) [Pubmed|27531959]
[PDB|5HS9] (quinone-bound form) [Pubmed|27531959]
[AF|O34844]
Modification
redox-controlled by intersubunit disulfide formation of Cys6 and Cys101' in response to quinones and diamide
Effectors of protein activity
responds distinctly to diamide or methyl-p-benzoquinone [Pubmed|27531959]
Paralogous protein(s)
[protein|91085DA5E71B88E533D2E1D1BFB53E908116C6AA|hypR], [protein|C57DDC9710CB557179B062F9C5D786DB02A3B5FC|ykvN], [protein|D9A187961CFB9496A6712E9E48AAD384357A3E1C|hxlR], [protein|E757C4B329A99E3D0C70C77437DF4DDA300CA5E7|ydzF], [protein|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|catR], [protein|51B1913B59C1876CCED4A88414797B3A22BE4E3C|ydeP], [protein|1E74F0557FF9ECB404B6544831F4E0A162473423|ytcD]
Expression and Regulation
Operons
genes
[gene|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB]
description
[pubmed|22383849]
regulatory mechanism
[protein|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB]: repression, in [regulon|protein:73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB regulon]
Biological materials
Mutant
MGNA-B433 (yodB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1432 NBRP B. subtilis, Japan]
BKE19540 ([gene|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE19540 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAGTCTTCATCCCTTCA, downstream forward: _UP4_TAAGGAAAGCGGCACCTGAA
BKK19540 ([gene|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK19540 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAGTCTTCATCCCTTCA, downstream forward: _UP4_TAAGGAAAGCGGCACCTGAA
labs
[wiki|Haike Antelmann],University of Greifswald, Germany
References
Reviews
Original Publications
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Time of last update: 2024-12-19 12:46:13
Author of last update: Melvin.boenninger