mneS

mneS
168

secondary manganese (II) efflux pump, contributes to iron efflux

Locus
BSU_06320
Molecular weight
31.63 kDa
Isoelectric point
5.63
Protein length
Gene length
Function
Mn(II) export
Product
manganese (II) efflux pump
Essential
no
Synonyms
mneS, undefined, ydxT, yeaB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0053 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
686,962  687,834
Phenotypes of a mutant
a mneP mneS double mutant is extremely senitive to Mn2+ intoxication, this results in generation of reactive radicals by poisoned cytochrome aa3 oxidase QoxA-QoxB-QoxC-QoxD and can be suppressed by inactivation of QoxA-QoxB-QoxC-QoxD (any gene) or of mhqR to activate the electrophile stress response PubMed
The protein
Catalyzed reaction/ biological activity
efflux of Mn(II) PubMed
efflux of iron PubMed
Protein family
Structure
5VRF (PDB) (from Shewanella oneidensis, 28% identity) PubMed
Paralogous protein(s)
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
Description
Regulatory mechanism
MntR: transcription activation, PubMed, in mntR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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mneS

2025-05-11 10:33:02

Bzhu

63

a6a6b660326f61d7f9ee99bd00edc6c82f2fcacb

2B854B46BCDA1050F8B8549DC32BFA53E7D54E43

Biological materials
Mutant
MGNA-A914 (yeaB::erm), available at the NBRP B. subtilis, Japan
BKE06320 (mneS::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATACAAAACCTCCTCTCGC,  downstream forward: _UP4_TAATGGAGCTTCCTGTCACA
BKK06320 (mneS::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATACAAAACCTCCTCTCGC,  downstream forward: _UP4_TAATGGAGCTTCCTGTCACA
References
Reviews
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Original Publications
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72BF9B934CB5800E156263FF377DED0AD2E920A9

Page visits: 4450

Time of last update: 2025-06-02 21:09:32

Author of last update: Jstuelk