mneS
168

secondary manganese (II) efflux pump, contributes to iron efflux

Locus

BSU_06320

Molecular weight

31.63 kDa

Isoelectric point

5.63

Protein length

290 aaSequenceBlast

Gene length

873 bpSequenceBlast

Function

Mn(II) export

Product

manganese (II) efflux pump

Essential

Synonyms

mneS, undefined, ydxT, yeaB

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0053 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

686,962 687,834

Phenotypes of a mutant

a mneP mneS double mutant is extremely senitive to Mn²⁺ intoxication, this results in generation of reactive radicals by poisoned cytochrome aa₃ oxidase QoxA-QoxB-QoxC-QoxD and can be suppressed by inactivation of QoxA-QoxB-QoxC-QoxD (any gene) or of mhqR to activate the electrophile stress response PubMed

The protein

Catalyzed reaction/ biological activity

efflux of Mn(II) PubMed

efflux of iron PubMed

Protein family

Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family PubMed

Structure

5VRF (PDB) (from Shewanella oneidensis, 28% identity) PubMed

P46348 (AlphaFold)

Paralogous protein(s)

YdbO, MneP

Localization