fnr

fnr
168

transcriptional regulator of anaerobic genes

locus
BSU_37310
Molecular weight
27.07 kDa
pI
5.99
Protein length
Gene length
function
regulation of anaerobiosis, fermentation and overflow metabolism
product
transcription regulator (Crp family)
essential
no
synonyms
fnr

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0664 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,831,512  3,832,228
The protein
[wiki|Domains]
HTH crp-type domain (aa 145-219) (according to UniProt)
[wiki|Cofactors]
[4Fe-4S] cluster [pubmed|29292548]
Structure
[AF|P46908]
Effectors of protein activity
contains an iron-sulfur cluster
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]
description
[Pubmed|8846791]
regulation
''[protein|search|fnr]'': expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10972836]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [Pubmed|10972836], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
[protein|EC6697D5D945B7E5083AFED9218748763C443278|nsrR]: repression, [Pubmed|16885456], in [regulon|protein:EC6697D5D945B7E5083AFED9218748763C443278|nsrR regulon]
[protein|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]: activation, [Pubmed|8846791,16428414], in [regulon|protein:7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8846791], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]

2024-11-02 01:03:09

ghost

63

fb9a04e01cb7ce25a7b9cf11ff636da30f848683

3E6FD5E26CEF0ED60159DFE03B533A4F29CECEE2

genes
[gene|F14481DAA196868ACC1DE9EC8CBE593A2CBB6BE4|narK]-[gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]
description
[Pubmed|8846791]
regulation
''[protein|search|fnr]'': expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10972836]
regulatory mechanism
[protein|EC6697D5D945B7E5083AFED9218748763C443278|nsrR]: repression, [Pubmed|16885456], in [regulon|protein:EC6697D5D945B7E5083AFED9218748763C443278|nsrR regulon]
[protein|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]: activation, [Pubmed|8846791,16428414], in [regulon|protein:7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8846791], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|F14481DAA196868ACC1DE9EC8CBE593A2CBB6BE4|narK]→[gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]

2024-12-07 18:09:52

ghost

75

238eac5527cfa8f31180009dd7b1e3d43c4bab0b

E61DAB2E4E2621BE034FA4B91DC19527F039482C

Biological materials
Mutant
BKE37310 ([gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE37310 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGAGCTCACCTCGAAGAA,  downstream forward: _UP4_TGAAAAAAACAAGGACAGCG
BKK37310 ([gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK37310 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGAGCTCACCTCGAAGAA,  downstream forward: _UP4_TGAAAAAAACAAGGACAGCG
References
Reviews
23046954,30225854
Other original publications
8682783,10972836,16885456,8846791,21068385,30225854
The [wiki|Fnr regulon]
16428414

7165CC59CDAF64AAE2D591936860304A53BE5DF6

Page visits: 4791

Time of last update: 2024-12-24 02:52:54

Author of last update: Melvin.boenninger