fnr
168
transcriptional regulator of anaerobic genes
locus
BSU_37310
Molecular weight
27.07 kDa
pI
5.99
function
regulation of anaerobiosis, fermentation and overflow metabolism
product
transcription regulator (Crp family)
essential
no
synonyms
fnr
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0664 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,831,512 3,832,228
The protein
[wiki|Domains]
HTH crp-type domain (aa 145-219) (according to UniProt)
[wiki|Cofactors]
[4Fe-4S] cluster [pubmed|29292548]
Structure
[AF|P46908]
Effectors of protein activity
contains an iron-sulfur cluster
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]
description
[Pubmed|8846791]
regulation
''[protein|search|fnr]'': expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10972836]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [Pubmed|10972836], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
[protein|EC6697D5D945B7E5083AFED9218748763C443278|nsrR]: repression, [Pubmed|16885456], in [regulon|protein:EC6697D5D945B7E5083AFED9218748763C443278|nsrR regulon]
[protein|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]: activation, [Pubmed|8846791,16428414], in [regulon|protein:7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8846791], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|F14481DAA196868ACC1DE9EC8CBE593A2CBB6BE4|narK]-[gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]
description
[Pubmed|8846791]
regulation
''[protein|search|fnr]'': expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10972836]
regulatory mechanism
[protein|EC6697D5D945B7E5083AFED9218748763C443278|nsrR]: repression, [Pubmed|16885456], in [regulon|protein:EC6697D5D945B7E5083AFED9218748763C443278|nsrR regulon]
[protein|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]: activation, [Pubmed|8846791,16428414], in [regulon|protein:7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8846791], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE37310 ([gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE37310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGAGCTCACCTCGAAGAA, downstream forward: _UP4_TGAAAAAAACAAGGACAGCG
BKK37310 ([gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK37310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGAGCTCACCTCGAAGAA, downstream forward: _UP4_TGAAAAAAACAAGGACAGCG
References
Reviews
Other original publications
The [wiki|Fnr regulon]
Page visits: 4791
Time of last update: 2024-12-24 02:52:54
Author of last update: Melvin.boenninger