remA
168
transcriptional regulator of the extracellular matrix genes, acts in parallel to [protein|5A6FBAE6553343092862CB79E150F934978C32A9|sinR], [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB], and [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]
locus
BSU_15670
Molecular weight
9.71 kDa
pI
7.18
function
control of biofilm formation
product
regulator of the extracellular matrix genes
essential
no
ec
null
synonyms
remA, ylzA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2052 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,641,672 1,641,941
The protein
Catalyzed reaction/ biological activity
binds [gene|FB2220730013A98D7C979062A4A451518B92DF09|opuAA], [gene|8C13E1EF5437DD8F9906643DEDCBB18DABE3B9E3|tapA], and [gene|F6C4634BF871D9A01E27014FFED7527C54BF560D|epsA] promoter regions (upstream of the actual promoter) to activate transcription [Pubmed|23646920]
binds DNA with high co-operativity due to low conserrvation of binding sites [Pubmed|23646920]
Protein family
RemA family (single member, according to UniProt)
Structure
[PDB|7BM2] [pubmed|34588455]
[AF|Q7WY72]
Expression and Regulation
Operons
genes
[gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]
description
[pubmed|22383849]
regulation
expressed during vegetative growth and early during sporulation in the forespore ([protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]) [Pubmed|23396918]
sigma factors
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|23396918], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
genes
[gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]-[gene|2B67C63442F28F6BCBA3BA6DE4B563C73E8DF16C|coaBC]-[gene|AF5ADDA2A98EC18BB72A81AA0336E639C0D1F430|priA]-[gene|3D41FB608DB70B9482312A1BBCCDBDA7FB713AFA|defA]-[gene|06971E9AAB033E2878914A76645F99E97CE8A90A|fmt]-[gene|1370D8783450D538C71E3DE8EA5B37DFEE073FF0|yloM]-[gene|5DEBD84E5937DB8B7F29C729FAA0076DF86A5451|yloN]
description
[pubmed|22383849]
genes
[gene|7821A09DADC6EAF589A882F05CC34BE900E06F2A|yloB]-[gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]
description
[pubmed|22383849]
regulation
expressed during sporulation in the mother cell [pubmed|12161109]
Biological materials
Mutant
BKE15670 ([gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE15670 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTCTACGTTCCCCCTG, downstream forward: _UP4_GATGAAGGGCAGGGGTAATT
BKK15670 ([gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK15670 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTCTACGTTCCCCCTG, downstream forward: _UP4_GATGAAGGGCAGGGGTAATT
labs
[wiki|Daniel Kearns], Indiana University, Bloomington, USA, [http://www.bio.indiana.edu/facultyresearch/faculty/Kearns.html homepage]
References
Reviews
Original Publications
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Time of last update: 2025-02-03 07:10:46
Author of last update: Jstuelk