roxS
168
small RNA, controls expression of [gene|B729EFC0BF0D75765C2D2B0B4F397E0AEE11F1E7|ytdI], [gene|D72175937B3956C2BC500FC00CEC8EC57A0A76A8|sucC]-[gene|5900CAC1CE367F33B267673A7FC210A3A269B30E|sucD], and [gene|73356B73D6C89D6569CECCC7295AF85CC7A1E6E3|yflS]
locus
BSU_misc_RNA_67
function
control of [gene|B729EFC0BF0D75765C2D2B0B4F397E0AEE11F1E7|ytdI], [gene|D72175937B3956C2BC500FC00CEC8EC57A0A76A8|sucC]-[gene|5900CAC1CE367F33B267673A7FC210A3A269B30E|sucD], and [gene|73356B73D6C89D6569CECCC7295AF85CC7A1E6E3|yflS] expression
product
trans-acting regulatory RNA
essential
no
synonyms
roxS, rsaE
Genomic Context
Categories containing this gene/protein
This gene is a member of the following regulons
RNA
Catalyzed reaction/ biological activity
hybridizes to [gene|B729EFC0BF0D75765C2D2B0B4F397E0AEE11F1E7|ytdI] and [gene|5900CAC1CE367F33B267673A7FC210A3A269B30E|sucD] mRNAs to inhibit their translation and to destabilize them [pubmed|25643072]
binds the 5' end of the [gene|73356B73D6C89D6569CECCC7295AF85CC7A1E6E3|yflS] mRNA to prevent its degradation by [wiki|rnjA|RNase J1] [pubmed|28436820]
Expression and Regulation
Operons
genes
[gene|6AC80B5916EEA851E9A7AF586341C58B7E69D8E7|roxS]
description
[pubmed|22383849]
regulation
induced by nitric oxide (NO) ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]) [pubmed|22383849]
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: transcriptional activation [pubmed|22383849]
[protein|B5EF521437323EF43F08E5EFDB5C798616CA499A|rex]: transcriptional repression [pubmed|28436820]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: transcriptional activation, [pubmed|22383849], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
[protein|B5EF521437323EF43F08E5EFDB5C798616CA499A|rex]: repression, [pubmed|28436820], in [regulon|protein:B5EF521437323EF43F08E5EFDB5C798616CA499A|rex regulon]
additional information
the [gene|6AC80B5916EEA851E9A7AF586341C58B7E69D8E7|roxS] RNA is degraded by the joined activities of RNase Y (initial endonucleolytic cleavage) and RNase J1 (processive degradation) [pubmed|22383849]
the [gene|6AC80B5916EEA851E9A7AF586341C58B7E69D8E7|roxS]-[gene|search|ppnKB] and [gene|6AC80B5916EEA851E9A7AF586341C58B7E69D8E7|roxS]-[gene|D72175937B3956C2BC500FC00CEC8EC57A0A76A8|sucC] RNA duplexes form a cleavage site for RNase III [pubmed|22383849]
References
Reviews
Research papers
Page visits: 1375
Time of last update: 2025-04-09 16:17:42
Author of last update: Jstuelk