nadR
168
transcriptional repressor of genes involved in NAD biosynthesis
locus
BSU_27890
Molecular weight
19.58 kDa
pI
5.76
function
regulation of NAD biosynthesis
product
transcriptional repressor
essential
no
synonyms
nadR, yrxA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1827 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,850,716 2,851,258
The protein
Structure
[PDB|1J5Y] (from Thermotoga maritima, 38% identity) [pubmed|17256761]
[AF|P39667]
Expression and Regulation
Operons
genes
[gene|A6746AE1B92A0CDCCB22B57B6DF78094BB0223A8|nifS]-[gene|510DE075EA964D22C42DEB171509F6CDA600A402|nadR]
description
[Pubmed|8444804]
regulation
repressed in the presence of nicotinic acid ([protein|search|NadR]) [Pubmed|8444804,16199587]
regulatory mechanism
[protein|510DE075EA964D22C42DEB171509F6CDA600A402|nadR]: repression, [Pubmed|8444804,16199587], in [regulon|protein:510DE075EA964D22C42DEB171509F6CDA600A402|nadR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8444804], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-A824 (yrxA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/824 NBRP B. subtilis, Japan]
BKE27890 ([gene|510DE075EA964D22C42DEB171509F6CDA600A402|nadR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCCTTCAGCCACAGAAGAA, downstream forward: _UP4_TAAAAAAAGCCCTCTAGTGG
BKK27890 ([gene|510DE075EA964D22C42DEB171509F6CDA600A402|nadR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCCTTCAGCCACAGAAGAA, downstream forward: _UP4_TAAAAAAAGCCCTCTAGTGG
labs
[wiki|Alessandra Albertini], University of Pavia, Italy [http://www-1.unipv.it/genbiom/albertini.html homepage]
References
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Time of last update: 2025-04-17 15:17:28
Author of last update: Jstuelk