mreBH

mreBH
168

cell shape-determining protein, forms filaments, the polymers control/restrict the mobility of the cell wall elongation enzyme complex, required for LytE activity

Locus
BSU_14470
Molecular weight
35.53 kDa
Isoelectric point
5.24
Protein length
335 aaSequenceBlast
Gene length
1008 bpSequenceBlast
Function
cell shape determation
Product
cell shape-determining protein
Essential
no
Synonyms
mreBH
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1077 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,516,574  1,517,581
The protein
Catalyzed reaction/ biological activity
forms ring-shaped filaments in a heterologous system PubMed
required for the activity of LytE PubMed
Protein family
FtsA/MreB family (according to UniProt)
Structure
1JCF (PDB) (MreB from Thermotoga maritima, 52% identity) PubMed
P39763 (AlphaFold)
Paralogous protein(s)
Mbl, MreB
Localization
during logarithmic growth, MreBH forms discrete patches thst move processively along peripheral tracks perpendicular to the cell axis PubMed
forms transverse bands as cells enter the stationary phase PubMed
close to the inner surface of the cytoplasmic membrane PubMed
reports on helical structures formed by MreBH PubMed seem to be misinterpretation of data PubMed
normal localization depends on the presence of glucolipids, MreB forms irregular clusters in an ''ugtP'' mutant PubMed
Expression and Regulation
Operons
Genes
mreBH-ykpC
Description
PubMed
Regulation
expression is increased in an ugtP mutant PubMed
induced at high temperature (SigI, WalR) PubMed
Regulatory mechanism
WalR: activation, PubMed, in walR regulon
Sigma factors
SigI: sigma factor, PubMed, in sigI regulon
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mreBH→ykpC

2025-03-17 19:14:20

Bzhu

103

7cc47a93f26f6b572b81b00be5d01512884305bd

130C5D74C19DDEB65F1EE7AD141A8B90C2CCF0F3

Biological materials
Mutant
BKE14470 (mreBH::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTTTCACCCAATCTCT,  downstream forward: _UP4_TAGTCTTTACCCGCAAAATT
BKK14470 (mreBH::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTTTCACCCAATCTCT,  downstream forward: _UP4_TAGTCTTTACCCGCAAAATT
References
Other original publications
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Localization
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40829C3632E9DCEB9E1C14A674B4B217F504CFE0

Page visits: 4485

Time of last update: 2025-04-03 21:34:57

Author of last update: TPed