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spoIIQ
168
component of the [protein|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH]-[protein|3282D2C25468776881778006F182FCF322C4821D|spoIIQ] type III secretion system residing in the forespore membrane, required for anchoring of proteins on both sides of the sporulation septum, required for localization and stability of [protein|7C8DFE00A2B2B30CC8BEB35055D92CC2E4128F3A|spoIIE]
Molecular weight
30.96 kDa
function
forespore encasement by the spore coat
product
part of the transmembrane channel linking the mother cell and the forespore
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
3,759,702 3,760,553
The protein
Catalyzed reaction/ biological activity
required for forespore encasement by the spore coat [Pubmed|22171814]
required for the recruitment of [protein|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH] to the [wiki|sporulation] septum on the mother cell side [Pubmed|23834622]
required for the proper localization and stability of [protein|7C8DFE00A2B2B30CC8BEB35055D92CC2E4128F3A|spoIIE] [Pubmed|38904397,26929302]
Structure
[PDB|3UZO]; [PDB|3TUF] (the [protein|3282D2C25468776881778006F182FCF322C4821D|spoIIQ]-[protein|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH] pore forming complex) [Pubmed|22431604,22431613]
[AF|P71044]
[wiki|Localization]
membrane protein, forms a transmembrane channel linking the mother cell and the forespore (with [protein|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH]) [Pubmed|22431604,22431613,22171814]
septal membranes on the forespore side [Pubmed|27381174]
proper [wiki|localization] requires [protein|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH], [protein|AA519F0D7DC94165C2CF5F7E230502D884898B71|gerM] and degradation of septal peptidoglycan by the cell wall hydrolases [protein|AAC4BF6FA80115AB90D2B161C1D5383625953616|spoIID] and [protein|C9817A54C8E72193280E393D7BD3375BD1751738|spoIIP] [Pubmed|23834622]
Expression and Regulation
Operons
genes
[gene|3282D2C25468776881778006F182FCF322C4821D|spoIIQ]
description
[Pubmed|9140963]
regulation
expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|16497325,15699190,9140963]
sigma factors
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|16497325,9140963], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
[gene|3282D2C25468776881778006F182FCF322C4821D|spoIIQ]
2025-01-25 13:08:34
ghost
71
4350f9e1d2ea60222fe48fe847c4ab0f46f3180c
9366D760CD732360053BB0564804339107E7AA25
Biological materials
Mutant
BKE36550 ([gene|3282D2C25468776881778006F182FCF322C4821D|spoIIQ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36550 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTTTCATCACCTCAGC, downstream forward: _UP4_TAATGAAGAAAACGTCTATC
BKK36550 ([gene|3282D2C25468776881778006F182FCF322C4821D|spoIIQ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36550 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTTTCATCACCTCAGC, downstream forward: _UP4_TAATGAAGAAAACGTCTATC
References
Reviews
23944268,25105965,31350897,32660383,33651833,35638784,29475625 Original Publications
18812514,15752199,18077456,18485064,15574594,15044948,15882622,19609349,9140963,20444098,17121846,18160039,21097616,16497325,15699190,22431613,22171814,23834622,22431604,23859254,25356555,26929302,27381174,33383000,33523946,38904397
