ytlP
168
similar to 2´-CPDase
locus
BSU_29960
Molecular weight
21.00 kDa
pI
8.5
function
nucleotide metabolism
product
putative 2´-CPDase
essential
no
synonyms
ytlP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1514 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,065,751 3,066,302
The protein
Catalyzed reaction/ biological activity
H2O + RNA(n)-2',3'-cyclic phosphate --> H+ + RNA(n)-2'- phosphate (according to UniProt)
Protein family
2H phosphoesterase superfamily (with [protein|5CA17CD28A725B8D7B87B9AAA167844042439794|yjcG], according to UniProt) [pubmed|31422053]
Structure
[PDB|1IUH] (from Thermus thermophilus, 24% identity) [pubmed|12798681]
[AF|O34570]
Paralogous protein(s)
[protein|5CA17CD28A725B8D7B87B9AAA167844042439794|yjcG]
Expression and Regulation
Operons
genes
[gene|29A38D244A07ED0973D0846B652238524F4DBC67|ytlP]-[gene|DB1491F13F8B55A360413E815E47A2B51D24395C|ytlQ]-[gene|ED4C1EA16FF96DA20F12B972CD2458FA3B49DDA5|ytlR]-[gene|7D783DD180D950A4B030BF5EA78CCE930A466A07|amyX]
description
[pubmed|22383849]
sigma factors
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|26577401], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
Biological materials
Mutant
MGNA-A431 (ytlP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/431 NBRP B. subtilis, Japan]
BKE29960 ([gene|29A38D244A07ED0973D0846B652238524F4DBC67|ytlP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29960 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCGTCTGACACTCCCTT, downstream forward: _UP4_TAATTCATTGCGGAGTGGAG
BKK29960 ([gene|29A38D244A07ED0973D0846B652238524F4DBC67|ytlP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29960 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCGTCTGACACTCCCTT, downstream forward: _UP4_TAATTCATTGCGGAGTGGAG
References
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Time of last update: 2025-04-06 21:03:10
Author of last update: Jstuelk