bacC

bacC
168

dihydroanticapsin 7-dehydrogenase

Locus
BSU_37720
Molecular weight
27.17 kDa
Isoelectric point
4.96
Protein length
255 aaSequenceBlast
Gene length
768 bpSequenceBlast
Function
biosynthesis of the antibiotic bacilysin
Product
dihydroanticapsin 7-dehydrogenase
Essential
no
Synonyms
bacC, ywfD, ipa-82d
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG1028 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,872,105  3,872,872
The protein
Catalyzed reaction/ biological activity
oxidation of the C(7)-hydroxyl, penultimate step in bacilysin biosynthesis PubMed
L-dihydroanticapsin + NAD+ --> H+ + L-anticapsin + NADH (according to UniProt)
Protein family
Short-chain dehydrogenases/reductases (SDR) family (according to UniProt)
Cofactors
NAD+ PubMed
Structure
5ITV (PDB) PubMed
P39640 (AlphaFold)
Paralogous protein(s)
YdaD, YkvO, YhxC, YhxD, YcdF, YhdF
YxbG, (41,1%)
YvrD, (32,1%)
Expression and Regulation
Operons
Genes
bacA-bacB-bacC-bacD-bacE-bacF
Description
PubMed
Regulation
heterogeneous expression, percentage of expressing cells increases during colonization of plant roots PubMed
Regulatory mechanism
CodY: repression, PubMed, in codY regulon
AbrB: repression, PubMed, in abrB regulon
ScoC: repression, PubMed, in scoC regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

bacA→bacF

2025-04-04 15:24:59

Jstuelk

113

7D644717829C1A41F65E52A4312081846FB55951

33F4BF1A14F6AC22A6ACC7091140A7F012E3837C

Biological materials
Mutant
MGNA-B669 (ywfD::erm), available at the NBRP B. subtilis, Japan
BKE37720 (bacC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GGTTTTATCGGTGAGGTTCA,  downstream forward: _UP4_CAATAGAGAAGGAGTGTTTT
BKK37720 (bacC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GGTTTTATCGGTGAGGTTCA,  downstream forward: _UP4_CAATAGAGAAGGAGTGTTTT
References
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20A7DBA142F3BF8DCAD9732BD908CE8CC79AA993

Page visits: 5864

Time of last update: 2025-04-08 01:23:22

Author of last update: Melvin.boenninger