yuaF

yuaF
168

NfeD2, role in maintaining membrane integrity during conditions of cellular stress, confers (together with [protein|61893B4EB53FBBB9AD8BEEEFFCEFD0FC64544D6F|floT]) resistance to cefuroxime

locus
BSU_31020
Molecular weight
18.46 kDa
pI
4.04
Protein length
Gene length
function
involved in the control of membrane fluidity
product
NfeD family protein NfeD2
essential
no
synonyms
yuaF, NfeD2

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
3,182,015 → 3,182,539
The protein
Catalyzed reaction/ biological activity
[protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW]-dependent expression of ''[gene|5D5D9A544295DD9B55C75A8CF47AB19935E740C6|fabF]'' and the ''[gene|FFBB9B236B7D532D45FE0593B793E28E051BE7A2|yuaF]-[gene|61893B4EB53FBBB9AD8BEEEFFCEFD0FC64544D6F|floT]-[gene|56345EA776E1C5664EF1F2D1AF5CE3E5F40AD442|yuaI]'' operon result in reduced membrane fluidity [Pubmed|21542858,22178969]
Protein family
NfeD family (with [protein|F6B0D27B434D81B7A680555E4457F266B6206B7D|yqeZ])
Structure
[PDB|2K14] [pubmed|18696230]
[AF|O32077]
[wiki|Localization]
cell membrane, in focal structures [Pubmed|22753055]
Expression and Regulation
Operons
genes
[gene|FFBB9B236B7D532D45FE0593B793E28E051BE7A2|yuaF]-[gene|61893B4EB53FBBB9AD8BEEEFFCEFD0FC64544D6F|floT]-[gene|56345EA776E1C5664EF1F2D1AF5CE3E5F40AD442|yuaI]
description
[Pubmed|9987136]
regulation
expressed upon cell wall stress ([protein|search|SigW]) [Pubmed|9987136]
sigma factors
[protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW]: sigma factor, [Pubmed|9987136], in [regulon|protein:3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW regulon]
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[gene|FFBB9B236B7D532D45FE0593B793E28E051BE7A2|yuaF]→[gene|56345EA776E1C5664EF1F2D1AF5CE3E5F40AD442|yuaI]

2024-09-30 00:21:29

ghost

103

74783017adee65e27092873295090d89cf25b0f3

66B745E665386FEAD42DAF4757FCE1AFBDCCD185

Biological materials
Mutant
MGNA-A212 (yuaF::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/212 NBRP B. subtilis, Japan]
BKE31020 (Δ[gene|FFBB9B236B7D532D45FE0593B793E28E051BE7A2|yuaF]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE31020 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAACTTCCTCATCCTTTCTT,  downstream forward: _UP4_TAACATAAAAGGAGGAATTT
BKK31020 (Δ[gene|FFBB9B236B7D532D45FE0593B793E28E051BE7A2|yuaF]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK31020 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAACTTCCTCATCCTTTCTT,  downstream forward: _UP4_TAACATAAAAGGAGGAATTT
References
18696230,9987136,22753055,27362352

FFBB9B236B7D532D45FE0593B793E28E051BE7A2

Page visits: 5715

Time of last update: 2024-10-04 07:30:11

Author of last update: Bzhu