bdr
168
thioredoxin reductase-like flavoprotein with bacillithiol-disulfide (BSSB) reductase activity, acts also as bacilliredoxin reductase
locus
BSU_22950
Molecular weight
36.18 kDa
pI
6.08
function
recycling of oxidized bacillithiol disulfide to the reduced form (BSH)
product
FAD-containing NADPH-dependent bacillithiol disulfide reductase
essential
no
synonyms
ypdA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0492 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,400,984 → 2,401,958
The protein
Catalyzed reaction/ biological activity
recycling of oxidized bacillithiol disulfide (BSSB) to the reduced form (BSH) [pubmed|30636083]
bacilliredoxin reductase activity [pubmed|33722570]
[wiki|Cofactors]
FAD
NADPH
Structure
[PDB|4ZN0] (from Methanosarcina mazei, 27% identity) [pubmed|30453601]
[AF|P50736]
[wiki|Localization]
cell membrane (according to Swiss-Prot)
Biological materials
Mutant
MGNA-A398 (ypdA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/398 NBRP B. subtilis, Japan]
BKE22950 (Δ[gene|FF7440B70CCB5A9C443944E0259D845A958EA279|bdr]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22950 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCTGTCAACTCCTGCG, downstream forward: _UP4_TAAAGATGAGGAGCATATGA
BKK22950 (Δ[gene|FF7440B70CCB5A9C443944E0259D845A958EA279|bdr]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22950 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCTGTCAACTCCTGCG, downstream forward: _UP4_TAAAGATGAGGAGCATATGA
References
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Time of last update: 2024-12-21 15:18:58
Author of last update: Jstuelk