luxS

luxS
168

S-ribosylhomocysteine lyase, autoinducer-2 production protein, required for surface spreading motility (sliding) of B. subtilis natto and biofilm formation

locus
BSU_30670
Molecular weight
17.57 kDa
pI
5.17
Protein length
157 aaSequenceBlast
Gene length
474 bpSequenceBlast
function
methionine salvage
product
S-ribosylhomocysteine lyase
essential
no
ec
4.4.1.21
synonyms
luxS, ytjB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1854 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,137,495 → 3,137,968
The protein
Catalyzed reaction/ biological activity
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine --> (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine (according to UniProt)
Protein family
luxS family (single member, according to UniProt)
Structure
[PDB|1JQW] (complex with homocysteine),  [PDB|1J98] [Pubmed|11601850]
[AF|O34667]
Effectors of protein activity
subject to feedback inhibition [Pubmed|19258532]
Expression and Regulation
Operons
genes
[gene|FF61DC6CA162EEC191CDFC802E721FCBD32EC098|luxS]
description
[Pubmed|9387221]
additional information
subject to feedback inhibition [http://www.ncbi.nlm.nih.gov/sites/entrez/19258532 PubMed]
Open in new tab

[gene|FF61DC6CA162EEC191CDFC802E721FCBD32EC098|luxS]

2024-10-11 05:47:15

ghost

55

59bee1682afcc081acd66ba477e9635f5dfb1281

503FE72136AE4E3F3B14AB8F32C7ACC0CEFBB288

genes
[gene|F942C0F4618FACEF35ACA629355BAC288556E7B6|ytiB]-[gene|FF61DC6CA162EEC191CDFC802E721FCBD32EC098|luxS]
description
[pubmed|22383849]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|26577401], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
Open in new tab

[gene|F942C0F4618FACEF35ACA629355BAC288556E7B6|ytiB]->[gene|FF61DC6CA162EEC191CDFC802E721FCBD32EC098|luxS]

2024-10-10 07:36:07

Bzhu

72

75926799ff2de1c9324aa7def16e549e605f52eb

BC92809DA5580B1417FA8A9D54A26A0EA0ADDFD9

Biological materials
Mutant
MGNA-B540 (ytjB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1539 NBRP B. subtilis, Japan]
1A953 ( ''luxS''::''cat''), [Pubmed|17056751], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A953&Search=1A953 BGSC]
BKE30670 (Δ[gene|FF61DC6CA162EEC191CDFC802E721FCBD32EC098|luxS]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE30670 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATAATGGCACTCTCCCCTT,  downstream forward: _UP4_TAAAATAGAAAGGACCTTTT
BKK30670 (Δ[gene|FF61DC6CA162EEC191CDFC802E721FCBD32EC098|luxS]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK30670 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATAATGGCACTCTCCCCTT,  downstream forward: _UP4_TAAAATAGAAAGGACCTTTT
References
11553770,19258532,9387221,16740951,26779171,17056751,11601850

FF61DC6CA162EEC191CDFC802E721FCBD32EC098

Page visits: 6508

Time of last update: 2024-10-14 08:35:20

Author of last update: Melvin.boenninger