cimH

cimH
168

transporter for citrate (proton symport)

locus
BSU_38770
Molecular weight
48.18 kDa
pI
6.55
Protein length
Gene length
function
citrate uptake
product
transporter for citrate (proton symport)
essential
no
synonyms
cimH, yxkJ

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3493 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,979,753 → 3,981,105
The protein
Catalyzed reaction/ biological activity
uptake of citrate (symport with protons) [Pubmed|11566984]
Protein family
sodium:citrate (SCF) symporter family (together with [protein|F8F62635AA87E4E3A255D6F8FC621EF40954B520|maeN], according to UniProt)
Structure
[PDB|5X9R] (from Klebsiella pneumoniae, 34% identity) [pubmed|28566738]
[AF|P94363]
Paralogous protein(s)
[protein|F8F62635AA87E4E3A255D6F8FC621EF40954B520|maeN]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B|cimH]
description
[Pubmed|21815947]
regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|10666464]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
additional information
the mRNA is substantially stabilized upon depletion of [gene|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [PubMed|21815947]
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[gene|FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B|cimH]

2024-10-03 17:21:12

ghost

65

149df7299eb9471922e4b283dde1bc3cbe518f2a

3A76ADF21BC7A81FAB283E3CBA9CB2E6E55D7F1E

Biological materials
Mutant
MGNA-B744 (yxkJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1743 NBRP B. subtilis, Japan]
BKE38770 (Δ[gene|FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B|cimH]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGAAAAACCTCCCCTAT,  downstream forward: _UP4_TGATCCCCGCAAGCAAGTTC
BKK38770 (Δ[gene|FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B|cimH]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGAAAAACCTCCCCTAT,  downstream forward: _UP4_TGATCCCCGCAAGCAAGTTC
GP4216 ([gene|FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B|cimH]::kan), available in Jörg Stülke's lab
References
Reviews
16339740
Original Publications
12525174,10666464,11566984,21815947,28566738

FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B

Page visits: 2672

Time of last update: 2024-10-07 00:03:52

Author of last update: Christoph.elfmann