cwlK
168
peptidoglycan hydrolytic L,D-endopeptidase
locus
BSU_02810
Molecular weight
18.97 kDa
pI
5.66
function
cell wall turnover
product
peptidoglycan hydrolytic L,D-endopeptidase
essential
no
synonyms
cwlK, ycdD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
303,804 → 304,307
The protein
Catalyzed reaction/ biological activity
cleaves the peptide bond between L-Ala (position 1 in the peptioglycan peptide) and D-Glu (position 2) [Pubmed|18266855]
Protein family
peptidase M15C family (single member, according to UniProt)
Structure
[PDB|6AKV] (from Bacillus phage B4, correpsonds to aa 61 ... 164, 51% identity) [pubmed|30518175]
[AF|O34360]
[wiki|Localization]
cell membrane [Pubmed|17588176]
Biological materials
Mutant
BKE02810 (Δ[gene|FCE68CB323C7FDFE09B1F88EAEB95D045A189AEB|cwlK]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCGGTCTCACTTTCTC, downstream forward: _UP4_GAGATGATTCCTAACTAGAC
BKK02810 (Δ[gene|FCE68CB323C7FDFE09B1F88EAEB95D045A189AEB|cwlK]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCGGTCTCACTTTCTC, downstream forward: _UP4_GAGATGATTCCTAACTAGAC
labs
[wiki|Ciaran Condon], IBPC, Paris, France [http://www.ibpc.fr/UPR9073/condon/index_en.html Homepage]
References
Reviews
Original Publications
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Time of last update: 2024-12-21 14:58:11
Author of last update: Jstuelk